Results 81 to 90 of about 54,370 (265)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Using the Lubrication Approximation to Model the Effects of Viscosity in DEM Simulations for Complex Flow Regimes

KONA Powder and Particle Journal
This study explores an efficient approach to modelling the flow of particles in wet granular systems using the Discrete Element Method (DEM). Typically, when particles move in a viscous fluid, DEM is coupled with Computational Fluid Dynamics (CFD) or ...
David N. de Klerk, Indresan Govender, Taswald L. Moodley, Aubrey N. Mainza   +3 more
doaj   +1 more source

Peristaltic flow of Eyring-Powell nanofluid under the action of an electromagnetic field

Engineering Science and Technology, an International Journal, 2019
Electro-kinetic peristaltic flow of Eyring-Powell nanofluid has been investigated in this paper. The flow is considered to take place in an asymmetric wavy micro-channel.
B. Mallick, J.C. Misra
doaj   +1 more source

Magnetohydrodynamic approximation of the complete equations for an electromagnetic fluid

Tsukuba Journal of Mathematics, 1986
The authors give a singular limit theorem for the magnetohydrodynamic equations in two space dimensions, which are obtained as the limit of the complete equations for the electromagnetic fluid at the vanishing of the dielectric constant. They show convergence of the solutions of the complete equations to the solutions of the magnetohydrodynamic ...
Kawashima, Shuichi, Shizuta, Yasushi
openaire   +5 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Hm Convergence of the Second-Grade Fluid Equations to Euler Equations in ℝd

Discrete Dynamics in Nature and Society, 2020
In this paper, we investigate an approximation of the Euler equation by the second-grade fluid equations in ℝdd=2,3. The convergence in Hm of a sequence of solutions to the second-grade fluid equations in a uniform interval is proven as both the ...
Hui Zhou
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The self power of a clamped circular plate. An analytical estimation

Archives of Acoustics, 2003
A low frequency approximation for the self power of a clamped crcular plate is presented in a form useful for some efficient numerical computations. The approximation is precise enough within nearly the whole low frequency range.
W. P. Rdzanek, W. J. Rdzanek
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source