Results 81 to 90 of about 461,621 (293)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Weakly Nonlinear Instability of a Convective Flow in a Plane Vertical Channel

Fluids
The weakly nonlinear stability analysis of a convective flow in a planar vertical fluid layer is performed in this paper. The base flow in the vertical direction is generated by internal heat sources distributed within the fluid.
Natalja Budkina, Valentina Koliskina, Andrei Kolyshkin, Inta Volodko   +3 more
doaj   +1 more source

Numerical simulation of the free convection in a viscous compressible fluid

Open Engineering, 2016
The numerical implementation of the classical model of thermal convection in a viscous compressible fluid in a finite domain is considered. Difference approximation carried out by the control volume method.
Perepechko Yury, Sorokin Konstantin, Imomnazarov Kholmatzhon   +2 more
doaj   +1 more source

A Two-Fluid Method for Ambipolar Diffusion

, 2008
We present a semi-implicit method for isothermal two-fluid ion-neutral ambipolar drift that is second-order accurate in space and time. The method has been implemented in the RIEMANN code for astrophysical fluid dynamics.
Balsara, Balsara, Balsara, Balsara, Balsara, Balsara, Balsara, Balsara, Basu, Blitz, Ciolek, Ciolek, David A. Tilley, Dinshaw S. Balsara, Draine, Draine, Falgarone, Falle, Fatuzzo, Indebetouw, Jiang, Jijina, Kudoh, Langer, Larson, Li, Li, Li, Lim, Mac Low, Mestel, Motte, Mouschovias, Mouschovias, Nakamura, O'Sullivan, O'Sullivan, Oishi, Pudritz, Roberge, Shu, Smith, Tóth, Tóth, Wardle, Zweibel   +45 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A New Solution of Drag for Newtonian Fluid Droplets in a Power-Law Fluid

Fluids
Understanding flow behaviors of multiple droplets in complex non-Newtonian fluids is crucial in many science and engineering applications. In this study, a new and improved analytical solution is developed based on the free surface cell model for the ...
Jianting Zhu
doaj   +1 more source

Computing absorbing times via fluid approximations [PDF]

Advances in Applied Probability, 2017
AbstractIn this paper we compute the absorbing timeTnof ann-dimensional discrete-time Markov chain comprisingncomponents, each with an absorbing state and evolving in mutual exclusion. We show that the random absorbing timeTnis well approximated by a deterministic timetnthat is the first time when a fluid approximation of the chain approaches the ...
Gast, Nicolas, Gaujal, Bruno
openaire   +3 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Influence of a Given Field of Temperature on the Blood Pressure Variation: Variational Analysis, Numerical Algorithms and Simulations

Axioms
This article presents a fluid–elastic structure interaction (FSI) problem when the temperature variation of the two media is also taken into account. We introduced the mathematical description of this interaction in a recent article.
Ruxandra Stavre, Alexandra Ciorogar
doaj   +1 more source