Results 31 to 40 of about 286,703 (251)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Perinatal risk factors for late neonatal severe acute kidney injury in very low birth weight infants: a retrospective study

Frontiers in Pediatrics
This study aimed to identify the perinatal risk factors of severe acute kidney injury (AKI) occurring after the first week of birth in very low birth weight (VLBW) infants who survived up to the first week.
Hyun Ho Kim, Hyun Ho Kim, Jihye You, Jihye You, Esther Park, Esther Park, Jin Kyu Kim, Jin Kyu Kim   +7 more
doaj   +1 more source

Effect of Thirst-Driven Fluid Intake on 1 H Cycling Time-Trial Performance in Trained Endurance Athletes

Sports, 2019
A meta-analysis demonstrated that programmed fluid intake (PFI) aimed at fully replacing sweat losses during a 1 h high-intensity cycling exercise impairs performance compared with no fluid intake (NFI).
Maxime Perreault-Briere, Jeff Beliveau, David Jeker, Thomas A. Deshayes, Ana Duran, Eric D. B. Goulet   +5 more
doaj   +1 more source

Association between Hepatic Venous Congestion and Adverse Outcomes after Cardiac Surgery

Diagnostics, 2022
Introduction: Hepatic venous flow patterns reflect pressure changes in the right ventricle and are also markers of systemic venous congestion. Fluid management is crucial in patients undergoing cardiac surgery.
Csaba Eke, András Szabó, Ádám Nagy, Balázs Szécsi, Rita Szentgróti, András Dénes, Miklós D. Kertai, Levente Fazekas, Attila Kovács, Bálint Lakatos, István Hartyánszky, Kálmán Benke, Béla Merkely, Andrea Székely   +13 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Evaluation of the clinical characteristics and outcomes of patients admitted to intensive care units after the Kahramanmaras (Türkiye) earthquake: a multicenter observational study

Frontiers in Medicine
IntroductionThe outcomes of patients admitted to intensive care units (ICUs) after earthquakes that occurred on the 6th of February 2023 in Türkiye are unknown.
Burcin Halacli, Goksel Guven, Esat Kivanc Kaya, Mehmet Yildirim, Nihal Deniz Bulut Yuksel, Gamze Kocak, Kadir Bulut, Derful Gulen, Begum Erdemir Sullu, Banu Kilicaslan, Asir Eren Seven, Emin Gemcioglu, Meltem Simsek, Recep Civan Yuksel, Sahin Temel, Ahmet Safa Kaynar, Kamil Deveci, Nilgun Alptekinoglu Mendil, Emre Aydin, Birkan Ulger, Aliye Esmaoglu, Nazlihan Boyaci Dundar, Ebru Ortac Ersoy, Kursat Gundogan, Seda Banu Akinci, Arzu Topeli   +25 more
doaj   +1 more source

IMPACT ОF TARGETED THERAPY WITH VARIOUS TYPES ОF SOLUTIONS ON RENAL FUNCTIONS IN THE PATIENTS UNDERGOING CARDIAC SURGERY

Вестник анестезиологии и реаниматологии, 2017
The article describes the impact of the targeted therapy with colloid and crystalloid infusion solutions on renal function and fluid balance during the surgery and early post-surgery period in the patients who underwent aortocoronary bypass under cardio ...
G. V. Moroz, E. V. Fominski, A. N. Shilova, V. A. Shmyrev, D. G. Shakhin, V. V. Lomivorotov   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source