Results 111 to 120 of about 6,139,729 (399)
Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
Fast, large amplitude vibrations of compliant cylindrical shells carrying a fluid [PDF]
arXiv, 2012 In this fluid dynamics video, we demonstrate the first three circumferential modes of fast, large amplitude vibrations of compliant cylindrical shells carrying a fluid.
arxiv
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Multiple Coexisting States of a Falling Viscous Thread [PDF]
arXiv, 2009 This article describes a fluid dynamics video submission for the 2009 Gallery of Fluid Motion, Division of Fluid Dynamics, American Physical Society.
arxiv
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Investigations into wastewater composition focusing on nonwoven wet wipes
Technical Transactions, 2017 This paper summarizes the problems caused for wastewater systems by changing wastewater composition, especially the increasing use of nonwoven wet wipes and their disposal via the toilet.
Mitchell Raja-Louisa +3 more
doaj +1 more source
Merger of vorticity holes [PDF]
arXiv, 2010 This paper contains background information for a fluid dynamics video submitted to the Gallery of Fluid Motion to be held along with the 63rd Annual Meeting of the American Physical Society's Division of Fluid Dynamics.
arxiv
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Flutter to tumble transition of buoyant spheres triggered by rotational inertia changes
Nature Communications, 2018 Spiral and zigzag trajectories of rising bubbles and falling leaves represent some of the path instabilities commonly observed for objects moving through fluids. Here, Mathai et al.
Varghese Mathai +3 more
doaj +1 more source