Results 71 to 80 of about 1,238,717 (284)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Photoacclimation and Photoadaptation Sensitivity in a Global Ocean Ecosystem Model

Journal of Advances in Modeling Earth Systems
Chlorophyll underpins ocean productivity yet simulating chlorophyll across biomes, seasons and depths remains challenging for earth system models. Inconsistencies are often attributed to misrepresentation of the myriad nutrient supply, growth and loss ...
Charles A. Stock, John P. Dunne, Jessica Y. Luo, Andrew C. Ross, Nicolas VanOostende, Niki Zadeh, Theresa J. Cordero, Xiao Liu, Yi‐Cheng Teng   +8 more
doaj   +1 more source

Prominence of the tropics in the recent rise of global nitrogen pollution

Nature Communications, 2019
Nitrogen pollution is influenced by many stressors, and their combined effects are poorly constrained. Here the authors used a global land biosphere model to analyse the past two and a half centuries of land N pollution budgets and fluxes to the ocean ...
Minjin Lee, Elena Shevliakova, Charles A. Stock, Sergey Malyshev, P. C. D. Milly   +4 more
doaj   +1 more source

On the Mean Residence Time in Stochastic Lattice-Gas Models

, 2018
A heuristic law widely used in fluid dynamics for steady flows states that the amount of a fluid in a control volume is the product of the fluid influx and the mean time that the particles of the fluid spend in the volume, or mean residence time.
Dall'Asta, Luca, Gamba, Andrea, Zamparo, Marco   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exploring multiyear-to-decadal North Atlantic sea level predictability and prediction using machine learning

npj Climate and Atmospheric Science
Coastal communities face substantial risks from long-term sea level rise and decadal sea level variations, with the North Atlantic and U.S. East Coast being particularly vulnerable under changing climates. Employing a self-organizing map-based framework,
Qinxue Gu, Liping Zhang, Liwei Jia, Thomas L. Delworth, Xiaosong Yang, Fanrong Zeng, William F. Cooke, Shouwei Li   +7 more
doaj   +1 more source

Aerodynamic force measurement algorithm based on U-Net in maglev flight wind tunnel

Kongqi donglixue xuebao
The aerodynamic force measurement technology during the acceleration phase of the motion model is one of the key technical challenges in the maglev flight wind tunnel. The aerodynamic force measurement balance is subjected to various strong interferences
Guoyao Deng, Zhe Hu, Dejun Xu, Jun Zhang, Zhangsong Ni   +4 more
doaj   +1 more source

Transvascular fluid dynamics

Veterinary Anaesthesia and Analgesia, 2000
To review the pathophysiology of fluid and macromolecular movement between the microvascular, interstitial and lymphatic spaces and provide a basis for logical intravenous colloid therapy.Medline (1966 - present), Commonwealth Agricultural Bureaux abstracts (1973 - present) and Personal files.
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Publisher Correction: Prominence of the tropics in the recent rise of global nitrogen pollution

Nature Communications, 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Minjin Lee, Elena Shevliakova, Charles A. Stock, Sergey Malyshev, P. C. D. Milly   +4 more
doaj   +1 more source