Results 71 to 80 of about 6,048,558 (383)

Knotted solutions, from electromagnetism to fluid dynamics

open access: yes, 2017
Knotted solutions to electromagnetism and fluid dynamics are investigated, based on relations we find between the two subjects. We can write fluid dynamics in electromagnetism language, but only on an initial surface, or for linear perturbations, and we ...
Alves, Daniel W. F.   +3 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Skillful seasonal prediction of wind energy resources in the contiguous United States

open access: yesCommunications Earth & Environment
A key challenge with the wind energy utilization is that winds, and thus wind power, are highly variable on seasonal to interannual timescales because of atmospheric variability.
Xiaosong Yang   +5 more
doaj   +1 more source

Steady linked vortices with chaotic streamlines

open access: yes, 2010
This paper contains background information for a fluid dynamics video submitted to the Gallery of Fluid Motion to be held along with the 63rd Annual Meeting of the American Physical Society's Division of Fluid Dynamics.Comment: 2 videos (high and low ...
Angélica Romero Arteaga   +8 more
core   +1 more source

Nonlinear mode decomposition with convolutional neural networks for fluid dynamics [PDF]

open access: yesJournal of Fluid Mechanics, 2019
We present a new nonlinear mode decomposition method to visualize decomposed flow fields, named the mode decomposing convolutional neural network autoencoder (MD-CNN-AE). The proposed method is applied to a flow around a circular cylinder at the Reynolds
Takaaki Murata, Kai Fukami, K. Fukagata
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

The dynamics of quantum fluids

open access: yes
We review experimental and theoretical progress in the physical description of the dynamics of the quantum fluids \he4 and \he3. Historically, the elementary excitations in these systems have been identified as phonons and rotons and, in \he3, collective zero sound and spin-fluctuations.
Godfrin, Henri, Krotscheck, Eckhard
openaire   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

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