Results 61 to 70 of about 1,253,068 (289)

Flow-dependent fluorescence of CCVJ

Journal of Biological Engineering, 2017
Background The molecular rotor 9-(2-Carboxy-2-cyanovinyl)julolidine (CCVJ) is presumed to have a sensitivity towards velocity or shear which is supposed to result in a change in fluorescence quantum yield. Furthermore, a previously reported photoisomeric
Markus J. Schmidt, David Sauter, Thomas Rösgen   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Recent increases in tropical cyclone intensification rates

Nature Communications, 2019
Tropical cyclones that rapidly intensify are associated with the highest forecast errors and the strongest storms. This study shows that the proportion of tropical cyclones that rapidly intensify recently increased in the Atlantic basin, and that this ...
Kieran T. Bhatia, Gabriel A. Vecchi, Thomas R. Knutson, Hiroyuki Murakami, James Kossin, Keith W. Dixon, Carolyn E. Whitlock   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Quantifying Equilibrium Climate Sensitivity to Atmospheric Chemistry and Composition Representations in GFDL‐CM4.0 and GFDL‐ESM4.1

Geophysical Research Letters
Equilibrium climate sensitivity (ECS) quantifies surface warming in response to doubled pre‐industrial CO2 (2xCO2). Uncertainty in estimates arises from diverse model representations and climate‐chemistry feedbacks.
L. T. Sentman, J. P. Dunne, L. W. Horowitz, V. Naik, F. Paulot, P. Ginoux, N. Zadeh   +6 more
doaj   +1 more source

Plane waves in noncommutative fluids

, 2013
We study the dynamics of the noncommutative fuid in the Snyder space perturbatively at the first order in powers of the noncommutative parameter. The linearized noncommutative fluid dynamics is described by a system of coupled linear partial differential
Abdalla, M. C. B., Holender, L., Santos, M. A., Vancea, I. V.   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

On the Flight Control of Flapping Wing Micro Air Vehicles with Model-Based Reinforcement Learning

Proceedings
Hummingbirds and insects can hover in disturbed conditions, escape from predators with a very fast response, fly for miles without landing, etc [...]
Romain Poletti, Lilla Koloszar, Miguel Alfonso Mendez   +2 more
doaj   +1 more source

Experimental observation of shear thickening oscillation

, 2013
We report experimental observation of the shear thickening oscillation, i.e. the spontaneous macroscopic oscillation in the shear flow of severe shear thickening fluid.
Mitarai, Namiko, Nagahiro, Shin-ichiro, Nakanishi, Hiizu   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source