Results 61 to 70 of about 242,124 (267)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Photoacclimation and Photoadaptation Sensitivity in a Global Ocean Ecosystem Model

Journal of Advances in Modeling Earth Systems
Chlorophyll underpins ocean productivity yet simulating chlorophyll across biomes, seasons and depths remains challenging for earth system models. Inconsistencies are often attributed to misrepresentation of the myriad nutrient supply, growth and loss ...
Charles A. Stock, John P. Dunne, Jessica Y. Luo, Andrew C. Ross, Nicolas VanOostende, Niki Zadeh, Theresa J. Cordero, Xiao Liu, Yi‐Cheng Teng   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Large eddy simulations of methane oxidation at ultra-wet conditions in a model gas turbine combustor applying detailed chemistry

Journal of Fluid Science and Technology, 2014
The addition of steam to the combustion process is a promising avenue, in order to reduce harmful emissions and simultaneously increase the efficiency. In contrast to traditional flames where the heat release exhibits a thin flame front, operating under ...
Oliver KRÜGER, Christophe DUWIG, Steffen TERHAAR, Christian Oliver PASCHEREIT   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Aerodynamic force measurement algorithm based on U-Net in maglev flight wind tunnel

Kongqi donglixue xuebao
The aerodynamic force measurement technology during the acceleration phase of the motion model is one of the key technical challenges in the maglev flight wind tunnel. The aerodynamic force measurement balance is subjected to various strong interferences
Guoyao Deng, Zhe Hu, Dejun Xu, Jun Zhang, Zhangsong Ni   +4 more
doaj   +1 more source

Prominence of the tropics in the recent rise of global nitrogen pollution

Nature Communications, 2019
Nitrogen pollution is influenced by many stressors, and their combined effects are poorly constrained. Here the authors used a global land biosphere model to analyse the past two and a half centuries of land N pollution budgets and fluxes to the ocean ...
Minjin Lee, Elena Shevliakova, Charles A. Stock, Sergey Malyshev, P. C. D. Milly   +4 more
doaj   +1 more source

The dynamics of quantum fluids

We review experimental and theoretical progress in the physical description of the dynamics of the quantum fluids \he4 and \he3. Historically, the elementary excitations in these systems have been identified as phonons and rotons and, in \he3, collective zero sound and spin-fluctuations.
Godfrin, Henri, Krotscheck, Eckhard
openaire   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source