Results 41 to 50 of about 242,124 (267)

Fluid–particle dynamics in canalithiasis [PDF]

Journal of The Royal Society Interface, 2008
The semicircular canals (SCCs; located in the inner ear) are the primary sensors for angular motion. Angular head movements induce a fluid flow in the SCCs. This flow is detected by afferent hair cells inside the SCCs. Canalithiasis is a condition where small particles disturb this flow, which leads to benign paroxysmal positional vertigo (top-shelf ...
Obrist, D, Hegemann, S
openaire   +4 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Fluid Dynamics of Bacterial Turbulence [PDF]

Physical Review Letters, 2013
Self-sustained turbulent structures have been observed in a wide range of living fluids, yet no quantitative theory exists to explain their properties. We report experiments on active turbulence in highly concentrated 3D suspensions of Bacillus subtilis and compare them with a minimal fourth-order vector-field theory for incompressible bacterial ...
Dunkel, Jörn, Heidenreich, Sebastian, Drescher, Knut, Wensink, Henricus H., Bär, Markus, Goldstein, Raymond E.   +5 more
openaire   +4 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

GFDL's SPEAR Seasonal Prediction System: Initialization and Ocean Tendency Adjustment (OTA) for Coupled Model Predictions

Journal of Advances in Modeling Earth Systems, 2020
The next‐generation seasonal prediction system is built as part of the Seamless System for Prediction and EArth System Research (SPEAR) at the Geophysical Fluid Dynamics Laboratory (GFDL) of the National Oceanic and Atmospheric Administration (NOAA ...
Feiyu Lu, Matthew J. Harrison, Anthony Rosati, Thomas L. Delworth, Xiaosong Yang, William F. Cooke, Liwei Jia, Colleen McHugh, Nathaniel C. Johnson, Mitchell Bushuk, Yongfei Zhang, Alistair Adcroft   +11 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Explicit Prediction of Continental Convection in a Skillful Variable‐Resolution Global Model

Journal of Advances in Modeling Earth Systems, 2019
We present a new global‐to‐regional model, cfvGFS, able to explicitly (without parameterization) represent convection over part of the Earth. This model couples the Geophysical Fluid Dynamics Laboratory Finite‐Volume Cubed‐Sphere Dynamical Core (FV3) to ...
Lucas M. Harris, Shannon L. Rees, Matthew Morin, Linjiong Zhou, William F. Stern   +4 more
doaj   +1 more source

Characterising Fatigue Behaviour of Nodular Cast Iron Using Micromechanical Simulations [PDF]

MATEC Web of Conferences, 2019
Elastic-plastic porous materials experience an increase in the mean void volume fraction when they are subjected to cyclic loading. This behavior is known both from the experiments and simulations in the literature.
Lukhi Mehul, Kuna Meinhard, Hütter Geralf   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source