Results 31 to 40 of about 4,601,994 (298)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Genetic Optimisation of a Free-Stream Water Wheel Using 2D Computational Fluid Dynamics Simulations Points towards Design with Fully Immersed Blades

Energies, 2022
A large-scale two-dimensional computational fluid dynamics study is conducted in order to maximise the power output and smoothness of power delivery of a free-stream water wheel, a low-impact hydropower device.
Abhishekkumar Shingala, Olivier Cleynen, Aman Jain, Stefan Hoerner, Dominique Thévenin   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Parallel computational fluid dynamics 2004 : multidisciplinary applications

, 2005
Parallel CFD 2004, the sixteenth international conference on Parallel Computational Fluid Dynamics and other modern scientific domains, has been held since May 24th till May 27th, 2004 in Las Palmas de Gran Canaria, Spain.
Ecer, A., Satofuka, N., Fox, Pat, Winter, Gabriel, Periaux, Jacques   +4 more
core   +1 more source

Influence of drag closures and inlet conditions on bubble dynamics and flow behavior inside a bubble column

Engineering Applications of Computational Fluid Mechanics, 2017
In this paper, the hydrodynamics of a bubble column is investigated numerically using the discrete bubble model, which tracks the dispersed bubbles individually in a liquid column.
Amjad Asad, Christoph Kratzsch, Rüdiger Schwarze   +2 more
doaj   +1 more source

On the Development of GFDL's Decadal Prediction System: Initialization Approaches and Retrospective Forecast Assessment

Journal of Advances in Modeling Earth Systems, 2021
Using GFDL's new coupled model SPEAR, we have developed a decadal coupled reanalysis/initialization system (DCIS) that does not use subsurface ocean observations.
Xiaosong Yang, Thomas L. Delworth, Fanrong Zeng, Liping Zhang, William F. Cooke, Matthew J. Harrison, Anthony Rosati, Seth Underwood, Gilbert P. Compo, Chesley McColl   +9 more
doaj   +1 more source

An Efficient Method for Computing the Power Potential of Bypass Hydropower Installations

Energies, 2022
Small-scale hydropower installations make possible a transition towards decentralized electrical power production with very low ecological footprint. However, the prediction of their power potential is difficult, because the incoming flow velocity and ...
Olivier Cleynen, Dennis Powalla, Stefan Hoerner, Dominique Thévenin   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Multiyear predictability of flood frequency along the U.S. Southeast Coast from Atlantic Meridional Overturning Circulation variability

Communications Earth & Environment
Observations have shown a significant increase in flood frequency along the U.S. Southeast Coast (USSEC) since the year 2010. This increased flooding is driven both by increases in storm frequency and rising background sea level due to increasing ...
Liping Zhang, Hiroyuki Murakami, Thomas L. Delworth, Vimal Koul, Andrew C. Ross, Charles Stock, Xiaosong Yang, Jaeyeon Lee, Andrew T. Wittenberg   +8 more
doaj   +1 more source