Results 101 to 110 of about 884,701 (313)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Unsteady flow and fluid transients [PDF]

open access: yes, 1992
This volume contains significant contributions on the prediction of unsteady flow and fluid transients in a wide variety of ...
Watts, J., Bettess, R.
core  

"Compensated hyperosmolarity" of cerebrospinal fluid and the development of hydrocephalus [PDF]

open access: yes, 2013
Acute osmolar loading of cerebrospinal fluid within one lateral ventricle of dogs was examined as a cause of water extraction from the bloodstream and an increase in intracranial pressure.
Vladić, Anton   +4 more
core   +1 more source

NUMERICAL SIMULATIONS OF GAP FLOW ABOVE ROTATING DISK

open access: yesTASK Quarterly, 2015
A rotating disk can be considered a basic configuration for the investigations of the impact of various conditions on the flow through the clearance between the shrouded turbine blade and the casing.
FILIP WASILCZUK   +2 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

UNSTEADY FLOW THROUGH THE GAP OF SAVONIUS TURBINE ROTOR

open access: yesTASK Quarterly, 2011
The paper presents a numerical analysis of unsteady flow through the gap of a Savonius turbine rotor, performed for varying integral turbine operating parameters calculated for the case under study as well as obtained from experiments described in the ...
JERZY ŚWIRYDCZUK   +2 more
doaj  

Rapid Prototyping of Microfluidics Devices using Xurograhy Method

open access: yesMATEC Web of Conferences, 2017
Rapid prototyping of microchannel gain lots of attention from researchers along with the rapid development of microfluidic technology. The conventional methods carried few disadvantages such as high cost, time consuming, required high operating pressure ...
Ling Fiona W.M.   +2 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

ON THE PREDICTION OF FLOW PATTERNS AND LOSSES IN HP AXIAL TURBINE STAGES USING 3D RANS SOLVER WITH TWO TURBULENCE MODELS

open access: yesTASK Quarterly, 2001
An experimentally tested air turbine stage and a real high-pressure (HP) steam turbine stage are calculated using the 3D RANS solver FlowER supplemented with the Baldwin-Lomax and Menter shear stress transport (SST) models. The computations of the model
PIOTR LAMPART   +2 more
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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