Results 121 to 130 of about 884,701 (313)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A note on withdrawal from a fluid of finite depth through a point sink [PDF]

, 2002
The problem of withdrawal through a point sink of water from a fluid of finite depth with a free surface is considered. Assuming the flow to be axisymmetric, it is found that there is a maximum Froude number at which such flows can exist.
Forbes, L.K., Hocking, G.C., Vanden-Broeck, J-M.   +2 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

The simulation of free surface flows with Computational Fluid Dynamics [PDF]

, 2008
Computational fluid dynamics is a powerful and versatile tool for the analysis of flow problems encountered in themaritime environment. The University of Southampton Fluid-Structure Interactions research group use ANSYS CFX tomodel a wide variety of flow
Tan, M., Godderidge, B, Hudson, D.A., Lewis, S.G., Turnock, S.R., Phillips, A.B., Godderidge, B.   +6 more
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Exergy optimization in a steady moving bed heat exchanger [PDF]

, 2007
Proceedings of: Interdisciplinary Transport Phenomena V: Fluid, Thermal, Biological, Materials and Space Sciences (ITP 2007), 14-19 of October, 2007, Bansko, Bulgaria (Oral paper nº 70)This work provides an exergy analysis of a moving bed heat exchanger
Soria Verdugo, Antonio, Ruiz-Rivas, Ulpiano, Soria-Verdugo, Antonio, Almendros Ibáñez, José Antonio, Ruiz-Rivas Hernando, Ulpiano, Almendros-Ibáñez, José Antonio, Santana Santana, Domingo José   +6 more
core  

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Cilia-mediated signalling in the embryonic nodes: A computational fluid-structure-protein interaction (FSPI) model [PDF]

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009), Norris, D, Chen, D, Ventikos, Y   +3 more
core  

METHOD FOR CALCULATING PERFORMANCE CHARACTERISTICS OF HYDROKINETIC TURBINES

TASK Quarterly, 2011
This paper presents a numerical algorithm and its computer implementation (program) developed to determine the operational characteristics of axial flow hydrokinetic turbines.
ADAM GÓRALCZYK, PATRYK CHAJA, ADAM ADAMKOWSKI   +2 more
doaj