Results 51 to 60 of about 2,038,662 (294)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
PROPOSAL OF MODERNISATION OF A STEAM TURBINE STAGE BEFORE EXTRACTION, CFD AND CSD ANALYSIS
TASK Quarterly, 2002 The paper presents an idea and analysis of application of a new solution of a stage before extraction in the modernised LP part of 200MW turbines with ND37 exhaust.
ANDRZEJ GARDZILEWICZ +6 more
doaj
Fluidic angular velocity sensor [PDF]
, 1986 A fluidic sensor providing a differential pressure signal proportional to the angular velocity of a rotary input is described. In one embodiment the sensor includes a fluid pump having an impeller coupled to a rotary input.
Berdahl, C. M.
core +1 more source
Longitudinal and transversal flow over a cavity containing a second immiscible fluid
, 2012 An analytical solution for the flow field of a shear flow over a rectangular cavity containing a second immiscible fluid is derived. While flow of a single-phase fluid over a cavity is a standard case investigated in fluid dynamics, flow over a cavity ...
Cherepanov +12 more
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Development of a computational framework for low-Reynolds number propeller aeroacoustics
Archives of MechanicsThe paper focuses on the development and validation of a new computational framework designed for the prediction of tonal and broadband noise radiation of propellers of unmanned aerial vehicles (UAVs) operating in the low-Reynolds number regime.
O. Szulc, T. Suresh, P. Flaszyński
doaj +1 more source
NOVEL ELECTROSTATIC WIND ENERGY CONVERTER: AN OVERVIEW
TASK Quarterly, 2015 The article discusses the historical development and embodiments of the concept of generating electricity from wind energy without the use of wind turbines, so called electrostatic bladeless generators or generators without moving parts.
HELENA NOWAKOWSKA +3 more
doaj +1 more source
Flow detectors having mechanical oscillators, and use thereof in flow characterization systems [PDF]
, 2003 An improved system (100), resonator flow detector (102) and method for characterizing a fluid sample that includes o injecting a fluid sample into a mobile phase of a flow characterization system (106), and detecting a property of the fluid sample > or ...
Kolosov, Oleg +2 more
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