Results 51 to 60 of about 608,013 (260)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
NUMERICAL SIMULATION OF MODEL HELICOPTER ROTOR IN HOVER
TASK Quarterly, 2008 The article presents details of a URANS simulation of the flow field near a hovering model of the Caradonna and Tung (1981) helicopter rotor [1]. The CFD code SPARC [2] proves to be capable of capturing the aerodynamics of a two -bladed rotor in high ...
PIOTR DOERFFER, OSKAR SZULC
doaj
Journal of Fluid Science and Technology, 2017 In order to examine mechanical interactions between erythrocytes and a blood vessel surface, the frictional characteristics between erythrocytes and plates in plasma have been measured by an inclined centrifuge microscope.
Suguru MIYAUCHI +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
HOLE EXTENSION EFFECT ON TRANSPIRATION FLOW EFFICIENCY
TASK Quarterly, 2015 The present analysis of the hole extension effect on the transpiration flow efficiency is a part of the research [1] which aims at defining a physical transpiration model of the flow through perforated plates.
TOMASZ LEWANDOWSKI, PIOTR DOERFFER
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
NUMERICAL SIMULATIONS OF GAP FLOW ABOVE ROTATING DISK
TASK Quarterly, 2015 A rotating disk can be considered a basic configuration for the investigations of the impact of various conditions on the flow through the clearance between the shrouded turbine blade and the casing.
FILIP WASILCZUK +2 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source