Results 71 to 80 of about 4,578,322 (240)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

UNSTEADY FLOW THROUGH THE GAP OF SAVONIUS TURBINE ROTOR

TASK Quarterly, 2011
The paper presents a numerical analysis of unsteady flow through the gap of a Savonius turbine rotor, performed for varying integral turbine operating parameters calculated for the case under study as well as obtained from experiments described in the ...
JERZY ŚWIRYDCZUK, PIOTR DOERFFER, MARIUSZ SZYMANIAK   +2 more
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

ON THE PREDICTION OF FLOW PATTERNS AND LOSSES IN HP AXIAL TURBINE STAGES USING 3D RANS SOLVER WITH TWO TURBULENCE MODELS

TASK Quarterly, 2001
An experimentally tested air turbine stage and a real high-pressure (HP) steam turbine stage are calculated using the 3D RANS solver FlowER supplemented with the Baldwin-Lomax and Menter shear stress transport (SST) models. The computations of the model
PIOTR LAMPART, JERZY ŚWIRYDCZUK, ANDRZEJ GARDZILEWICZ   +2 more
doaj  

Rapid Prototyping of Microfluidics Devices using Xurograhy Method

MATEC Web of Conferences, 2017
Rapid prototyping of microchannel gain lots of attention from researchers along with the rapid development of microfluidic technology. The conventional methods carried few disadvantages such as high cost, time consuming, required high operating pressure ...
Ling Fiona W.M., Mahmood Wafaa K., Abdulbari Hayder A.   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Inviscid mean flow through and around groups of bodies [PDF]

, 2004
General estimates are derived for mean velocities through and around groups or arrays of fixed and moving bodies, in unbounded and bounded domains, which lie within a defined perimeter.
Hunt, J. C. R., Hunt, J.C.R., Eames, I, Eames, I. (author), S. E. BELCHER, Belcher, S. E., J. C. R. HUNT, Eames, I., Hunt, JCR, Belcher, S.E. (author), Hunt, J.C.R. (author), Belcher, S.E., Belcher, SE, I. EAMES   +13 more
core   +2 more sources

TOWARDS THE DESIGN OF LOW NOISE LEVEL WIND TURBINES

TASK Quarterly, 2009
According to the authors’ hypothesis generation of high intensity noise is caused by generation of vorticity structures inducing velocities that can be locally higher than the velocity of sound.
PATRYK CHAJA , TADEUSZ KORONOWICZ
doaj  

Influence of the Spray Scrubber Geometry on the Efficiency of Dust Removal – Theoretical Predictions and CFD Analysis

Journal of Applied Fluid Mechanics, 2020
The article presents a method of purification of synthesis gas (syngas) produced as a result of biomass gasification with the use of a spray scrubber. The authors focus on the presentation of how individual elements of the geometry of a spray scrubber ...
A. Tomaszewski, T. Przybylinski, P. Kapica, M. Lackowski   +3 more
doaj  

INFLUENCE OF MEMBRANE AMPLITUDE AND FORCING FREQUENCY ON SYNTHETIC JET VELOCITY

TASK Quarterly, 2015
This paper presents the results of numerical investigations of a synthetic jet actuator for an active flow control system. The Moving Deforming-Mesh method as a boundary condition is used to capture the real physical phenomenon.
MARCIN KUROWSKI, PIOTR DOERFFER
doaj   +1 more source