Results 61 to 70 of about 111,147 (309)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysis of heat and mass transfer rates in conducting Casson fluid flow over an expanding surface considering Ohmic heating and Darcy dissipation effects

Partial Differential Equations in Applied Mathematics
In a recent scenario, the flow of Casson fluid via porous media has practical applications in various engineering processes, such, as the design of cooling systems for electronic devices, oil recovery in porous reservoirs, and polymer extrusion processes,
Rupa Baithalu, S.R. Mishra, P.K. Pattnaik, Subhajit Panda   +3 more
doaj   +1 more source

A Linear Mathematical Formulation to Minimize Intermediate Fluid Flow in Batch Heat Exchanger Networks

Chemical Engineering Transactions, 2018
In heat integration of batch process, heat storage plays an important role. In batch processes heat can be transported from a prior time zone to later time zone via heat storage.
Nitin Dutt Chaturvedi
doaj   +1 more source

Influence of Mass Transfer Processes on Couette Flow of Magnetic Fluid

Журнал нано- та електронної фізики, 2013
This article describes the results of a theoretical study of magnetic fluid two-dimensional Couett flow in magnetic fluid seal model in view of mass transfer processes. It has been shown that very inhomogeneous magnetic field in seal gap lead to magnetic particle concentration rearrangement due to magnetophoresis and Brownian diffusion.
Bashtovoi, V.G., Pogirnitskaya, S.G., Kuzhir, R., Polunin, V.M., Ryapolov, P.A., Shabanova, I.A., Storozhenko, A.M.   +6 more
openaire   +3 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Numerical Investigation and Thermal Performance Analysis of Smooth Absorber Tube in a Parabolic Trough Solar Collector [PDF]

E3S Web of Conferences
The thermal efficiency of parabolic trough solar collectors (PTSCs) is highly dependent on the design and material characteristics of the absorber tubes that control the performance of heat transfer and fluid flow.
Sodiqova Nigora, Jumayev Bakhodir, Djurayeva Munira, Bobojonova Madina, Usmonov Firdavs   +4 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Boundary layer flow and heat-mass transfer of shear-thinning nanofluid past a thin needle: Electroperiodic magnetic field and thermo-diffusion effects

Nuclear Engineering and Technology
Heat and mass transfer in a boundary layer flow (BLF) of shear-thinning nanofluid (NF) around a thin needle has various practical applications including industrial processes, like medical devices, complicated cooling systems, high-efficiency thermal ...
Samia Nasr, Sohail Rehman, Sami Znaidia, Waqas Ahmed   +3 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source