Results 91 to 100 of about 12,595 (293)
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
Numerical simulation of post-fracturing flowback considering fracturing fluid imbibition
Shenzhen Daxue xuebao. Ligong ban, 2023 Fracturing fluid flowback is a key step in the process of hydraulic fracturing, and the imbibition of fracturing fluid in unconventional tight reservoirs cannot be ignored. Based on the oil-water two-phase seepage theory, Bernoulli equation and the continuity equation, we establish a numerical simulation model of post-fracturing flowback by considering
WANG Jiwei +4 more
openaire +1 more source
A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals
Advanced Science, EarlyView.This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao +16 more
wiley +1 more source
A Multiscale Study on Shale Wettability: Spontaneous Imbibition Versus Contact Angle
Water Resources Research, 2019 Environmental and technical issues associated with hydraulic fracturing fluid leak‐off and its low recovery in clay‐rich shale reservoirs has challenged the energy sector.
Mohammed Abdul Qadeer Siddiqui +3 more
doaj +1 more source
Dynamic Matrix-Fracture Transfer Behaviour in Dual-Porosity Models [PDF]
, 2012 Imperial Users ...
Su, Shi, Su, Shi
core
Advanced Science, EarlyView.RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo +9 more
wiley +1 more source
Advanced Science, EarlyView.This study maps the spatiotemporal distribution of hydrophobic toxicants and endogenous metabolites in the developing placenta and fetus. By integrating mass spectrometry imaging with snRNA‐seq, we identify SR‐B1 as a key transporter driving early‐gestation xenobiotic transfer and reveal a critical exposure window associated with persistent fetal ...
Yixuan Huang +10 more
wiley +1 more source
Journal of Rock Mechanics and Geotechnical EngineeringForced imbibition, the invasion of a wetting fluid into porous rocks, plays an important role in the effective exploitation of hydrocarbon resources and the geological sequestration of carbon dioxide. However, the interface dynamics influenced by complex
Jianchao Cai +4 more
doaj +1 more source
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu +20 more
wiley +1 more source