Results 131 to 140 of about 335,525 (308)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Advances and Trends in Fluid Inclusion Research in Denmark

, 1995
Geologi, fluid ...
Konnerup-Madsen, Jens, Rose-Hansen, John
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Influencing Factors of Hydrocarbon Migration and Adjustment at the Edge of a Stable Cratonic Basin: Implications from Fluid Inclusions, Quantitative Fluorescence Techniques, and Geochemical Tracing

Energies
Understanding the mechanisms of hydrocarbon migration, accumulation, and alteration, particularly how evolution controls these processes, is critical for exploring lithologic hydrocarbons in reservoirs. In the complex tectonic settings of the continental
Zhengqi Yang, Xin Cheng, Siqi Ouyang, Zhe Liu, Yuting Cheng, Shuqi Lan, Lei Xue, Ting Zhang, Yiqian Qu   +8 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Museums as Agents for Social Inclusion. The Inclusive Memory experience

, 2019
The problem of social exclusion / inclusion troubles the Western world with significant consequences on the well-being of all citizens. Exclusion or social inclusion are dimensions of the same construct that appears in itself particularly fluid in its ...
Poce Antonella
core  

Dogan copper deposit (south of Shahroud): copper-molybdenum porphyry mineralization in the Toroud-Chah Shirin magmatic arc

Journal of Economic Geology
The Dogan copper-molybdenum deposit is located in the northern Central Iranian magmatic arc, south of Shahrood. Mineralization in this area is caused by the injection of a microdioritic subvolcanic intrusion into Eocene volcanic rocks.
Mohadeseh Eskandari, Maryam Sheibi , Fardin Mousivand, Bernd Lehmann   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

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The analysis of stable isotopes within fluid inclusions represents a powerful tool in reconstructing past environmental and climatic conditions. Fluid inclusions, minute pockets of ancient water trapped within minerals such as speleothems, preserve the ...
Ahmed, Aqeel Ahmed Tanseer
core  

Gold mineralization in the Um El Tuyor area, South Eastern Desert, Egypt

, 2004
This thesis reports petrographic, mineralogical and geochemical data that constrain the hydrothermal alteration and gold mineralization in the Um El Tuyor area, SE Egypt.
Zoheir, Basem
core