Results 121 to 130 of about 335,525 (308)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The web of inclusion a new architecture for building great organizations
, 1995 The twenty-first century economy is fluid, technology-driven, based on creativity and relationships. Yet most businesses and organizations are still structured like nineteenth-century factories, forcing workers into cookie cutter roles.
Helgesen, Sally 1948-
core
Endolithic colonization of fluid inclusion trails in mineral grains [PDF]
, 2005 Many scenarios for the colonization of planetary surfaces by microbial life involve endoliths.
Cockell, C. S., Parnell, J., Baron, M.
core
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Frontiers in Earth ScienceIn this paper, the Binnan molybdenum (Mo) deposit, a newly discovered deposit located in the Great Xing’an Range, eastern section of the Central Asian Orogenic Belt, has been subjected to a comprehensive integrated study involving field surveys, rhenium ...
Zhongyou Qi +6 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Grain-boundary fluid inclusion interaction in rocks and analogues
, 2011 This thesis deals with the interaction of moving grain boundaries with fluid inclusions in metamorphic rocks and rock analogues. The grain scale distribution of fluids, the fluid inclusion morphology and kinetics have important implications for the ...
Schmatz, Joyce
core +1 more source
SUSURLUK (BALIKESİR) "OKSİDAN TİP" W-SKARNININ MİKROTERMOMETRİK ÖZELLİKLERİ
Bulletin of the Mineral Research and Exploration, 2010 Susurluk skarn yatağı, Çataldağ Granitoyidi ile Mesozoyik yaşlı karbonatlı kayaçların dokanağında gelişmiş olup, endo ve ekzoskarn (proksimal zon, distal zon ve damar skarnları) zonları ile temsil edilmektedir.
Ayşe ORHAN +2 more
doaj