Results 101 to 110 of about 2,739,725 (241)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

SUSURLUK (BALIKESİR) "OKSİDAN TİP" W-SKARNININ MİKROTERMOMETRİK ÖZELLİKLERİ

Bulletin of the Mineral Research and Exploration, 2010
Susurluk skarn yatağı, Çataldağ Granitoyidi ile Mesozoyik yaşlı karbonatlı kayaçların dokanağında gelişmiş olup, endo ve ekzoskarn (proksimal zon, distal zon ve damar skarnları) zonları ile temsil edilmektedir.
Ayşe ORHAN, Halim MUTLU, Nurullah HANİLÇİ   +2 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Geochemical, microthermometric, and geochronological characterization of the newly discovered Binnan molybdenum deposit in the great Xing’an Range, northeast China: insights into ore genesis

Frontiers in Earth Science
In this paper, the Binnan molybdenum (Mo) deposit, a newly discovered deposit located in the Great Xing’an Range, eastern section of the Central Asian Orogenic Belt, has been subjected to a comprehensive integrated study involving field surveys, rhenium ...
Zhongyou Qi, Shipan Tian, Guibin Sun, Gang Sun, Alam Masroor, Xiaoyu Li, Bingying Du   +6 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Central Europe temperature constrained by speleothem fluid inclusion water isotopes over the past 14,000 years. [PDF]

Sci Adv, 2019
Affolter S, Häuselmann A, Fleitmann D, Edwards RL, Cheng H, Leuenberger M.   +5 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Senior teacher perceptions towards inclusion [PDF]

, 2001
Plan BResearch has been conducted on the perceptions that teachers have towards the inclusion of students with disabilities into the regular education classroom.
Larson, Shawna A.
core  

Fluid inclusion petrology and microthermometry of the Cocos Ridge hydrothermal system, IODP Expedition 344 (CRISP 2), Site U1414. [PDF]

Geochem Geophys Geosyst, 2016
Brandstätter J, Kurz W, Krenn K, Micheuz P.   +3 more
europepmc   +1 more source