Results 91 to 100 of about 2,739,725 (241)

Table C.2: Fluid inclusion data of CO2+-N2 inclusions of dark rock types from Petermannketten

, 2002
Table C.2: Fluid inclusion data of CO2+-N2 inclusions of dark rock types from ...
Kleinefeld, Bärbel, Bärbel Kleinefeld (6974519)   +1 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Table C.4: Fluid inclusion data of H2O-salt inclusions of dark rocks from Petermannketten

, 2002
Table C.4: Fluid inclusion data of H2O-salt inclusions of dark rocks from ...
Kleinefeld, Bärbel, Bärbel Kleinefeld (6974519)   +1 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

(Table 1) Fluid inclusion analyses of minerals from ODP Hole 118-735B

, 2001
(Table 1) Fluid inclusion analyses of minerals from ODP Hole 118 ...
Kelley, Deborah S, Gretchen L Frueh-Green (6971186), Frueh-Green, Gretchen L, Deborah S Kelley (6974609)   +3 more
core   +1 more source

Influencing Factors of Hydrocarbon Migration and Adjustment at the Edge of a Stable Cratonic Basin: Implications from Fluid Inclusions, Quantitative Fluorescence Techniques, and Geochemical Tracing

Energies
Understanding the mechanisms of hydrocarbon migration, accumulation, and alteration, particularly how evolution controls these processes, is critical for exploring lithologic hydrocarbons in reservoirs. In the complex tectonic settings of the continental
Zhengqi Yang, Xin Cheng, Siqi Ouyang, Zhe Liu, Yuting Cheng, Shuqi Lan, Lei Xue, Ting Zhang, Yiqian Qu   +8 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Dogan copper deposit (south of Shahroud): copper-molybdenum porphyry mineralization in the Toroud-Chah Shirin magmatic arc

Journal of Economic Geology
The Dogan copper-molybdenum deposit is located in the northern Central Iranian magmatic arc, south of Shahrood. Mineralization in this area is caused by the injection of a microdioritic subvolcanic intrusion into Eocene volcanic rocks.
Mohadeseh Eskandari, Maryam Sheibi , Fardin Mousivand, Bernd Lehmann   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source