Results 71 to 80 of about 1,022,309 (304)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Hydrocarbon charge history of deeply buried clastic reservoirs in the Bozi area of the Kuqa Depression, western China: implications for deep and ultra-deep petroleum exploration

Frontiers in Earth Science
Significant progress has recently been made in deep and ultra-deep oil and gas exploration globally, demonstrating enormous exploration potential of the deep and ultra-deep strata. However, the accumulation and preservation pattern of deep and ultra-deep
Peng Yang, Peng Yang, Yaya Song, Keyu Liu, Keyu Liu, Keyu Liu, Shunyu Wang, Shunyu Wang, Xinzhuo Wei, Xinzhuo Wei, Jianliang Liu, Jianliang Liu   +11 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Bulk viscous Zel'dovich fluid model and it's asymptotic behavior

, 2015
In this paper we have considered a flat FLRW universe with bulk viscous Zel'dovich as the cosmic component. Being considered the bulk viscosity as per the Eckart formalism, we have analyzed the evolution of the Hubble parameter and constrained the model ...
K., Rajagopalan Nair, Mathew, Titus K.
core   +1 more source

Viscous Cosmology for Early- and Late-Time Universe [PDF]

, 2017
From a hydrodynamicist's point of view the inclusion of viscosity concepts in the macroscopic theory of the cosmic fluid would appear most natural, as an ideal fluid is after all an abstraction (excluding special cases such as superconductivity).
Brevik, Iver, de Haro, Jaume, Grøn, Øyvind, Odintsov, Sergei D., Saridakis, Emmanuel N.   +4 more
core   +3 more sources

Do fluid inclusions preserve δ18O values of hydrothermal fluids in epithermal systems over geological time? : evidence from paleo- and modern geothermal systems, Milos island, Aegean Sea [PDF]

, 2003
Stable isotope compositions of quartz (δ18Oquartz) and fluid inclusion waters (δ18OFI and δDFI) were analysed from Profitis Ilias, a low-sulphidation epithermal gold mineralisation deposit on Milos island Greece, to establish if δ18OFI preserve a record ...
Cheliotis, I., Kilias, S.P., Leng, M.J., Naden, Jonathan, Shepherd, T.J.   +4 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Fluid inclusions in Martian samples: Clues to early crustal development and the hydrosphere [PDF]

Major questions about Mars that could be illuminated by examining fluid inclusions in Martian samples include: (1) the nature, extent and timing of development (and decline) of the hydrosphere that existed on the planet; and (2) the evolution of the ...
Brown, Philip E.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source