Results 151 to 160 of about 117,004 (351)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Fluid inclusions in hydrothermally synthesized brucite crystals.

, 1976
Kazuo Nakamura, SHIN-ICHI HIRANO, SHIGEYUKI SOMIYA   +2 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Exceptional Concentrations of Gold Nanoparticles in 1,7 Ga Fluid Inclusions From the Kola Superdeep Borehole, Northwest Russia. [PDF]

Sci Rep, 2020
Prokofiev VY, Banks DA, Lobanov KV, Selektor SL, Milichko VA, Akinfiev NN, Borovikov AA, Lüders V, Chicherov MV.   +8 more
europepmc   +1 more source

Macroscopic inclusions of fluid in British flourites from the mineral collection of the British Museum ( Natural History)

, 1978
Andrew H. Rankin, Frank L. Greenway
openalex   +1 more source

Lead isotopic ratios, ICP and XRF analyses, and fluid inclusion data from the Kady Zn-Pb-Cu-Ag vein-breccia prospect, northern Brooks Range, Alaska [PDF]

, 1998
M. B. Werdon
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Solid and fluid phases in lherzolite and pyroxenite inclusions from the Hoggar, central Sahara.

, 1982
Christine Miller, W. J. Richter
openalex   +2 more sources

EPITHERMAL Cu-Au MINERALIZATION IN THE PALAI-ISLICA DEPOSIT, ALMERIA, SOUTHEASTERN SPAIN: FLUID-INCLUSION EVIDENCE FOR MIXING OF FLUIDS AS A GUIDE TO GOLD MINERALIZATION [PDF]

, 2000
Salvador Morales-Ruano, Javier Carrillo-Rosúa, P. Fenoll Hach-Alí, Fernando de la Fuente Chacón, E. C. Lopez   +4 more
openalex   +1 more source