Results 131 to 140 of about 37,365 (307)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Methane in Fluid Inclusions in Ophiolitic Chromitites Revealed by Raman Spectroscopy: Preliminary Results

This contribution provides a petrographic and Raman investigation of fluid inclusions found in chromitites collected in the ophiolites of Santa Elena (Costa Rica), Bracco (Italy), Otrhys and Vourinos (Greece), and Troodos (Cyprus).
Mauro, Daniela, Daniela Mauro, Economou-Eliopoulos, Maria, Biagioni, Cristian, Federica Zaccarini, Garuti, Giorgio, Hegedűs, Máté, Gabriella B. Kiss, Máté Hegedűs, Giorgio Garuti, Maria Economou-Eliopoulos, Baloghné Kiss, Gabriella, Zaccarini, Federica, Cristian Biagioni   +13 more
core   +1 more source

Chemical and isotopic analyses of hydrocarbon-bearing fluid inclusions in olivine-rich rocks. [PDF]

Philos Trans A Math Phys Eng Sci, 2020
Grozeva NG, Klein F, Seewald JS, Sylva SP.   +3 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

P-T condition fo deformation from fluid inclusions in mylonites

, 1990
Structural petrology of fluid inclusions in deformed rocks can be used to identify inclusions entrapped during various stages of deformation. Standard thermobarometry on these inclusions can then provide estimates of the P-T (pressure-temperature ...
Mclellan, Eileen
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Evaluating seawater chemistry from fluid inclusions in halite: examples from modern marine and nonmarine environments

, 2001
Fluid inclusions from marine halites have long been studied to determine the chemical composition of ancient seawater. Chemical analyses of the major ions in fluid inclusions in halites from the solar saltwork of Great Inagua Island, Bahamas, and from ...
H Zimmermann, M.N Timofeeff, S.T Brennan, R.V Demicco, Demicco, R. V., Zimmermann, Heike, Horita, J., J Horita, Timofeeff, M. N., L.E von Borstel, T.K Lowenstein, Lowenstein, T. K., von Borstel, L. E., Brennan, S. T.   +13 more
core   +1 more source

Exceptional Concentrations of Gold Nanoparticles in 1,7 Ga Fluid Inclusions From the Kola Superdeep Borehole, Northwest Russia. [PDF]

Sci Rep, 2020
Prokofiev VY, Banks DA, Lobanov KV, Selektor SL, Milichko VA, Akinfiev NN, Borovikov AA, Lüders V, Chicherov MV.   +8 more
europepmc   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source