Results 111 to 120 of about 112,724 (302)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Magmatic and Metamorphic Fluids in Pegmatite Development: Evidence from Borujerd Complex, Iran [PDF]

open access: yesJournal of Sciences, Islamic Republic of Iran, 2005
The Borujerd complex of western Iran is composed of intrusions and their surrounding contact aureole, with, pegmatites and quartz veins. Pegmatites differ in mineralogy, origin and age, and two groups can be distinguished. The Older Pegmatites (about 120
doaj  

Ingredients for microbial life preserved in 3.5 billion-year-old fluid inclusions. [PDF]

open access: yesNat Commun, 2021
Mißbach H   +6 more
europepmc   +1 more source

Transport in polymer-gel composites: Theoretical methodology and response to an electric field

open access: yes, 2006
A theoretical model of electromigrative, diffusive and convectivetransport polymer-gel composites is presented. Bulk properties are derived from the standard electrokinetic model with an impenetrable charged sphere embedded in an electrolyte-saturated ...
Hill, Reghan J.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sources of the fluids for metasomatic magnesite of Ismakaevo deposit in the South Ural province (thermokryometry of fluid inclusions)

open access: yesЛитосфера, 2015
Bittern brine nature of fluid inclusions in magnesite of Ismakaevo deposits are confirmed not only by data of Cl-Br ion systematics, but also by methods of microthermometry.
M. T. Krupenin, A. A. Garaeva
doaj   +2 more sources

Hydrodynamic Collective Effects of Active Protein Machines in Solution and Lipid Bilayers

open access: yes, 2015
The cytoplasm and biomembranes in biological cells contain large numbers of proteins that cyclically change their shapes. They are molecular machines that can function as molecular motors or carry out many other tasks in the cell.
Kapral, Raymond, Mikhailov, Alexander
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

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