Results 121 to 130 of about 37,365 (307)
, 2010 Le but de cette thèse est de valider l'utilisation d'un laser femtoseconde à lumière infrarouge comme alternative efficace pour l'ablation contrôlée et reproductible d'inclusions fluides naturelles ou synthétiques.
Courtieu, Clément
core
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Characterization of H2S bearing fluid inclusions
, 1984 Rarely described until recently, fluid inclusions with H2S as a major component have been studied in various samples of quartz, fluorite and calcite. The phase behaviour at low temperatures of H2S-bearing inclusions (sometimes containing solid S or C ...
Guilhaumou, Nicole, Touray, Jean-Claude
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
An experimental investigation on fluid transfer mechanisms in ultramafic rocks
, 2019 Static annealing and crack-cook experiments were performed on wet and dry fabricated San Carlos olivine aggregates and a core of Balsam Gap dunite to investigate fluid infiltration mechanisms for low-permeability mantle rocks.
Zimmerman, Mark E. +2 more
core +1 more source
Frontiers in Earth ScienceFluid inclusions are a window into deep geological fluids, providing unique access to their nature and composition. The isotopic composition of CO2 and CH4 hosted in fluid inclusions is a powerful proxy to assess the origin and transformation of deep ...
Orlando Sébastien Olivieri +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Fluid inclusions in magmatic ilmenite record degassing in basic magmas
International audienceMagmatic volatile phases play a major role in igneous systems, but indirect sampling of the magmatic fluid, especially for basic magmas, remains challenging to document.
Gloaguen, Eric +10 more
core +1 more source