Results 61 to 70 of about 30,517 (264)

Fluid inclusions in reservoirs of Weixinan Sag, Beibuwan Basin

open access: yesPetroleum Exploration and Development, 2008
: To make sure the petroleum migrating direction and pool-forming model in the Weixinan sag, 4 wells were chosen to do research on fluid inclusions and petrography. The petroleum inclusions have three types: type I occurs in early cracks of quartz debris
Ping LIU   +4 more
doaj   +1 more source

Gas migration for terrestrial gas hydrates in the Juhugeng mining area of Muli basin, Qilian Mountains, Northwest China

open access: yesEnergy Exploration & Exploitation, 2020
The Juhugeng mining area in the Qilian Mountains is the only district of China where terrestrial gas hydrate has been found. This paper aimed at studying the gas migration for gas hydrates based on fluid inclusion and apatite fission track experiments ...
Anmin Wang   +5 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

2D Hydro‐Mechanical‐Chemical Modeling of (De)hydration Reactions in Deforming Heterogeneous Rock: The Periclase‐Brucite Model Reaction

open access: yesGeochemistry, Geophysics, Geosystems, 2020
Deformation at tectonic plate boundaries involves coupling between rock deformation, fluid flow, and metamorphic reactions, but quantifying this coupling is still elusive.
Stefan M. Schmalholz   +4 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Characteristics of Ore-forming Fluid and Mineralization of Jinqingding Gold Deposit in Mouru Metallogenic Belt, Jiaodong

open access: yesKuangchan zonghe liyong
The Mouru Gold Metallogenic Belt is one of the three major one in the Jiaodong Gold Metallogenic Zone. The Jinqingding Gold Deposit is located in the southern part of the metallogenic belt and is a large quartz vein-type gold one. The research on its ore-
Qian SONG   +5 more
doaj   +1 more source

Fluid charging and hydrocarbon accumulation in the Cambrian Longwangmiao Formation of Moxi Structure, Sichuan Basin, SW China

open access: yesPetroleum Exploration and Development, 2018
: The multi-stage minerals filled in pore space were sequenced, and the charging stages of fluid and hydrocarbon were reconstructed based on the observation of drilling cores and thin sections, homogeneous temperature testing of fluid inclusions, Laser ...
Fanghao XU   +3 more
doaj   +1 more source

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