Results 61 to 70 of about 390,010 (302)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Increasing weaning age of piglets from 4 to 7 weeks reduces stress, increases post-weaning feed intake but does not improve intestinal functionality [PDF]

, 2010
This study tested the hypothesis that late weaning and the availability of creep feed during the suckling period compared with early weaning, improves feed intake, decreases stress and improves the integrity of the intestinal tract.
Dekker, R.A., Hoogendoorn, A., Koopmans, S.J., Meulen, J., van der   +3 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Korelasi antara asupan cairan, kalium, natrium dengan interdialytic weight gain pada pasien hemodialisis rutin

Jurnal Gizi Klinik Indonesia
Correlation between fluid intake, potassium, sodium, and interdialytic weight gain (IDWG) in routine hemodialysis patients Background: Chronic kidney failure patients undergo hemodialysis regularly to help kidney function. One of the problems that often
Defa Nuzul Nabilah, Windi Indah Fajar Ningsih, Rostika Flora, Sari Bema Ramdika   +3 more
doaj   +1 more source

Impaired Fluid Intake, but Not Sodium Appetite, in Aged Rats Is Mediated by the Cyclooxygenase-Prostaglandin E2 Pathway

Frontiers in Aging Neuroscience, 2020
Aging results in decreased fluid intake following dehydration and other dipsogenic stimuli; similar reductions in sodium intake have also been observed with aging.
Denovan P. Begg, Andrew J. Sinclair, Richard S. Weisinger   +2 more
doaj   +1 more source

Engaging Patients to Improve Documentation of Oral Intake on a Cardiac Telemetry Unit: A Quality Improvement Initiative [PDF]

, 2015
Background InformationIt is important for patients with heart failure to have awareness of their intake & output to effectively manage their disease.
Mosher, Timiny A
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Impact of mask wearing time on fluid consumption and physical activity during the COVID-19 pandemic

Frontiers in Nutrition
PurposeTo examine the associations between mask-wearing on fluid consumption and physical activity behaviors during the COVID-19 pandemic.Methods137 college students (female, 72.5%; age, 26 ± 9 y) completed a survey detailing their fluid intake, physical
Mitchell E. Zaplatosch, Mitchell E. Zaplatosch, Cory L. Butts, Samantha E. Scarneo-Miller, William M. Adams, William M. Adams, William M. Adams, William M. Adams   +7 more
doaj   +1 more source

Case study of a female ocean racer: prerace preparation and nutritional intake during the Vendee Globe 2008. [PDF]

, 2012
The Vendée Globe is a solo round-the-world sailing race without stopovers or assistance, a physically demanding challenge for which appropriate nutrition should maintain energy balance and ensure optimum performance.
Brightmore, A, Cooke, CB, Fearnley, D, King, R, O'Hara, J, Sutton, L   +5 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source