Results 71 to 80 of about 254,781 (304)
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Fluid machines: Expanding the limits, past and future [PDF]
During the 40 yr period from 1940 to 1980, the capabilities and operating limits of fluid machines were greatly extended. This was due to a research program, carried out to meet the needs of aerospace programs. Some of the events are reviewed.
Hartmann, M. J., Sandercock, D. M.
core +1 more source
Instabilities of geared couplings: Theory and practice [PDF]
, 1982 The use of couplings for high speed turbocompressors or pumps is essential to transmit power from the driver. Typical couplings are either of the lubricated gear or dry diaphragm type design.
Kirk, R. G., Mondy, R. E., Murphy, R. C.
core +1 more source
Design of the optimized and downsized axial fan for the air carrier orchard sprayers [PDF]
, 2016 The new vineyard and orchard installations are made with a high intensity of plants per hectare and therefore with a reduced distance between the rows. The tractors and the air carrier sprayers for plant protection, must therefore have smaller width.
Friso, Dario
core +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Advanced 3-D viscous SSME turbine rotor stator CFD algorithms [PDF]
Current Space Shuttle Main Engine (SSME) high pressure fuel turbopump problems have generated a desire to analyze the flow field of rotating machinery.
Janus, J. Mark, Whitfield, David L.
core +1 more source
Linear force and moment equations for an annular smooth shaft seal perturbed both angularly and laterally [PDF]
, 1982 Coefficients are derived for equations expressing the lateral force and pitching moments associated with both planar translation and angular perturbations from a nominally centered rotating shaft with respect to a stationary seal.
Dijulio, R. +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu +11 more
wiley +1 more source
Agricultural Water ManagementThe accurate estimation of the infiltration boundary of a buried point source is required in the hydraulic design of a subsurface drip irrigation (SDI) system, as well as in the numerical simulation of soil water movement.
Jian Wang +6 more
doaj +1 more source
Aerodynamic stiffness of an unbound eccentric whirling centrifugal impeller with an infinite number of blades [PDF]
, 1982 An unbounded eccentric centrifugal impeller with an infinite number of log spiral blades undergoing synchronous whirling in an incompressible fluid is considered.
Allaire, P. E. +2 more
core +1 more source