Results 51 to 60 of about 55,131 (262)

TRENDS AND CONSTRAINTS FOR FLUID POWER IN MOBILE MACHINERY [PDF]

Proceedings of the JFPS International Symposium on Fluid Power, 2008
The development of fluid power systems for use in agricultural and construction machinery faced in the last years a substantial contribution due to the increasing role played by electronics. The scenario of the next years in agricultural and construction will be very much influenced by legislation constraints in terms of environmental compatibility ...
openaire   +4 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Characteristics of limited flow and soil water infiltration boundary of a subsurface drip irrigation emitter in silty loam soil

Agricultural Water Management
The accurate estimation of the infiltration boundary of a buried point source is required in the hydraulic design of a subsurface drip irrigation (SDI) system, as well as in the numerical simulation of soil water movement.
Jian Wang, Zuokun Tian, Ting Yang, Xuechun Li, Qiu He, Duo Wang, Rui Chen   +6 more
doaj   +1 more source

Influence of the empirical coefficients of cavitation model on predicting cavitating flow in the centrifugal pump

International Journal of Naval Architecture and Ocean Engineering, 2014
The phenomenon of cavitation is an unsteady flow, which is nearly inevitable in pump. It would degrade the pump performance, produce vibration and noise and even damage the pump.
Liu Hou-lin, Wang Jian, Wang Yong, Zhang Hua, Huang Haoqin   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

PROPOSAL OF MODERNISATION OF A STEAM TURBINE STAGE BEFORE EXTRACTION, CFD AND CSD ANALYSIS

TASK Quarterly, 2002
The paper presents an idea and analysis of application of a new solution of a stage before extraction in the modernised LP part of 200MW turbines with ND37 exhaust.
ANDRZEJ GARDZILEWICZ, MICHAŁ KARCZ, STANISŁAW MARCINKOWSKI, MARCIN BIELECKI, JANUSZ BADUR, ALEKSANDER MALEC, MARIUSZ BANASZKIEWICZ   +6 more
doaj  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source