Genetic variation affecting exon skipping contributes to brain structural atrophy in Alzheimer's disease [PDF]
, 2018 Genetic variation in cis-regulatory elements related to splicing machinery and splicing regulatory elements (SREs) results in exon skipping and undesired protein products.
Alzheimer’s Disease Neuroimaging Initiative +8 more
core
Assessment of RANS turbulence models and Zwart cavitation model empirical coefficients for the simulation of unsteady cloud cavitation [PDF]
, 2019 The numerical simulation of unsteady cavitation flows is sensitive to the selected models and associated parameters. Consequently, three Reynolds Average Navier-Stokes (RANS) turbulence models and the Zwart cavitation model were selected to assess their ...
Escaler Puigoriol, Francesc Xavier +1 more
core +2 more sources
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Investigations of Marine Safety Improvements by Structural Health Monitoring Systems [PDF]
TransNav, 2012 The paper presents a first approach of the structural health monitoring (SHM) system, dedicated to marine structures. The considered system is based on the fibre optic (FO) technique with Fibre Bragg Grating (FBG) sensors.
Lech Murawski +5 more
doaj
SHOCK WAVE INDUCED FLOW SEPARATION CONTROL BY AIR-JET AND ROD VORTEX GENERATORS
TASK Quarterly, 2015 Flow separation control by Vortex Generators (VGs) has been analyzed over the last decades. The majority of the research concerning this technology has been focused on subsonic flows where its effectiveness for separation reduction has been proven. Less
FERNANDO TEJERO +2 more
doaj +1 more source
Increasing of reliability of work of rotating machines of oil and gas industry [PDF]
, 2013 The paper proposes two ways to improve the reliability of rotating machinery of oil and gas industry through the use of rolling bearings that allow evenly distribute the pressure of lubricating fluid to the surface of the ...
Bilyavskyi, М. L., Flunt, О. R.
core
Numerical and experimental design study of a regenerative pump [PDF]
, 2010 This paper presents the use of a commercial CFD code to simulate the flow-field within the regenerative pump and compare the CFD results with new experimental data.
Quail, Francis J. +2 more
core +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Length Scale of Free Stream Turbulence and Its Impact on Bypass Transition in a Boundary Layer
Journal of Applied Fluid Mechanics, 2017 An experimental investigation was carried out to study the turbulent flow over a flat plate in a subsonic wind tunnel. The enhanced level of turbulence was generated by five wicker grids with square meshes, and different parameters (diameter of the grid ...
J. Grzelak, Z. Wierciński
doaj +2 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source