Results 41 to 50 of about 55,131 (262)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Investigations of Marine Safety Improvements by Structural Health Monitoring Systems [PDF]
TransNav, 2012 The paper presents a first approach of the structural health monitoring (SHM) system, dedicated to marine structures. The considered system is based on the fibre optic (FO) technique with Fibre Bragg Grating (FBG) sensors.
Lech Murawski +5 more
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Length Scale of Free Stream Turbulence and Its Impact on Bypass Transition in a Boundary Layer
Journal of Applied Fluid Mechanics, 2017 An experimental investigation was carried out to study the turbulent flow over a flat plate in a subsonic wind tunnel. The enhanced level of turbulence was generated by five wicker grids with square meshes, and different parameters (diameter of the grid ...
J. Grzelak, Z. Wierciński
doaj +2 more sources
PARALLELIZED NUMERICAL CODE FOR DERIVATION OF HEAT TRANSFER COEFFICIENT FROM EXPERIMENTAL DATA
TASK Quarterly, 2015 An application of parallel computation capabilities in the MATLAB language for the analysis of experimental data concerning the heat transfer coefficient on ribbed walls is presented in this paper.
JANUSZ TELEGA +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Natural vibration frequencies of delaminated composite beams
Computer Assisted Methods in Engineering and Science, 2023 In the presented work a model of a layered, delaminated composite beam based on the finite elements method was introduced. In this model the beam was divided into finite elements, while the delamination was modelled using additional boundary conditions.
Marek Krawczuk +2 more
doaj
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source