Results 61 to 70 of about 1,007,541 (342)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Pulmonary tuberculosis followed by sarcoidosis in an HIV-infected patient: a case report and a simplified diagnostic flowchart for diagnosis and treatment of sarcoidosis [PDF]

, 2016
The diagnosis of sarcoidosis in a patient living with HIV infection is an uncommon event and a challenge for clinicians. Clinical manifestations are variable and fluctuating depending to adherence to ARV therapy and to the level of CD4 count.
Ascoli Bartoli, T., Baiocchini, A., Bellagamba, R., Corpolongo, A., De Nardo, P., Del Nonno, F., Ghirga, P., Giancola, M. L., Mencarini, P., Narciso, P., Nicastri, E., Oliva, A.   +11 more
core   +6 more sources

Management of Elderly Burn Patients

International Journal of Gerontology, 2008
Burn injuries are the principal reasons accounting for emergency department admissions in elderly patients. Elderly patients over 65 years of age constitute between 13% and 20% of admissions to burn units, but have the highest death rate among the ...
Shin-Bin Huang, Wen-Han Chang, Chein-Hsuan Huang, Cheng-Ho Tsai   +3 more
doaj   +1 more source

Causal Anomalies in Kaluza-Klein Gravity Theories [PDF]

, 1998
Causal anomalies in two Kaluza-Klein gravity theories are examined, particularly as to whether these theories permit solutions in which the causality principle is violated. It is found that similarly to general relativity the field equations of the space-
A. F. F. TEIXEIRA, Accioly A. J., Banerjee A., Billyard A., Chatterjee S., Coley A. A., Fukui T., M. J. REBOUÇAS, Ma G.-W., Novello M., Oliveira J. D., Raychaudhuri A. K., Rebouças M. J., Rebouças M. J., Smalley L. L., Teixeira A. F. F., Wesson P. S., Wesson P. S., Wesson P. S., Wesson P. S.   +19 more
core   +3 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Can the inferior vena cava collapsibility index be useful in predicting hypotension during spinal anaesthesia in a spontaneously breathing patient? A mini fluid challenge

Acta Medica Lituanica, 2019
The study was performed at the Department of Orthopaedics and Traumatology of the Kauno Klinikos Hospital of Lithuanian University of Health Sciences. Background.
Inna Jaremko, Asta Mačiulienė, Arūnas Gelmanas, Tautvydas Baranauskas, Ramūnas Tamošiūnas, Alfredas Smailys, Andrius Macas   +6 more
doaj   +1 more source

Progression to Severe Hypernatremia in Hospitalized General Medicine Inpatients: An Observational Study of Hospital-Acquired Hypernatremia

Medicina, 2020
Background and objectives: Hypernatremia can be community or hospital-acquired, and there may be specific factors unique to the hospital environment, such as intravenous fluid treatment, which contribute to hypernatremia.
Ramessh Ranjan, Stacey C.-Y. Lo, Stephanie Ly, Visakan Krishnananthan, Andy K.H. Lim   +4 more
doaj   +1 more source

Intravenous fluid therapy [PDF]

British Journal of Surgery, 2009
Management ...
openaire   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

ASPECTOS CLÍNICOS DA INFUSÃO INTRAPERITONEAL EM BOVINOS

Colloquium Agrariae, 2015
The maintenance and the proper concentration of ions are essential for homeostasis in animals. Some diseases such as hypocalcemia, hypoglycemia, diarrhea among others, commonly affect cattle, leading to eletrolute an acid base imbalances. Fluid therapy
Wilmar Sachetin Marçal, André Hiroshi Quadros Watanabe   +1 more
doaj   +1 more source