Results 81 to 90 of about 656,113 (361)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Fluid therapy for the high-risk patient undergoing surgery

, 2018
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Ward, PA, Liu, SE, Irwin, MG
core   +1 more source

Understanding Volume Kinetics: The Role of Pharmacokinetic Modeling and Analysis in Fluid Therapy

Frontiers in Veterinary Science, 2020
Fluid therapy is a rapidly evolving yet imprecise clinical practice based upon broad assumptions, species-to-species extrapolations, obsolete experimental evidence, and individual preferences. Although widely recognized as a mainstay therapy in human and
Xiu Ting Yiew, Shane W. Bateman, Robert G. Hahn, Robert G. Hahn, Alexa M. E. Bersenas, William W. Muir   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery : the FOCCUS study [PDF]

, 2011
Peer ...
Campbell, MK, Stott, Stephen A., Seonaidh C Cotton, Daniela Rae, Cook, Jonathan, Rae, Daniela, Elders, Andrew, Grant, Adrian, Brian H Cuthbertson, Grant, A, Stott, Stephen A, Cook, J, Addison, Jennifer, Campbell, Marion K, Stephen A Stott, Campbell, Marion K., Hernández, R, Stott, SA, Cuthbertson, Brian H., Kinsella, John, Adrian Grant, Boyers, Dwayne, David Alcorn, null null, Alcorn, D, Kinsella, J, Cuthbertson, Brian H, Boyers, D, Norrie, John, Dwayne Boyers, Andrew Elders, The FOCCUS study group, Hernández, Rodolfo, Elders, A, Rodolfo Hernández, Julie Brittenden, Addison, J, Brittenden, Julie, Alcorn, David, Cotton, SC, John Norrie, Rae, D, Brittenden, J, Cotton, Seonaidh C, Cuthbertson, BH, Cotton, Seonaidh C., Marion K Campbell, Norrie, J, Jennifer Addison, John Kinsella, Jonathan Cook   +50 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Individualizing Fluid Management in Patients with Acute Respiratory Distress Syndrome and with Reduced Lung Tissue Due to Surgery—A Narrative Review

, 2023
Fluids are the cornerstone of therapy in all critically ill patients. During the last decades, we have made many steps to get fluid therapy personalized and based on individual needs.
Jan Benes, Jakub Kletecka, Olga Smekalova, Jan Zatloukal, Jiri Kasperek, Vaclav Tegl   +5 more
core   +1 more source

Balancing Maternal Cardiac Risk and Anaesthetic Safety: A Case Series on Segmental Spinal Anaesthesia [PDF]

Journal of Clinical and Diagnostic Research
Pregnancy evokes significant alterations to the physiologic conditions in females and it is more dramatic for women suffering from valvular heart diseases or congenital cardiovascular diseases. Increases in blood volume and cardiac output, as well as the
Roshani Nitin Manwani, Prachi Korde, Anjali Borkar, Amreesh Paul Francis   +3 more
doaj   +1 more source

The clinical condition rather than cerebrospinal fluid parameters guides the optimal duration of antimicrobial therapy among neonates with bacterial meningitis: a single-center retrospective study [PDF]

, 2022
Ya Hu, Xingyuan Li, Hong Wei, Hongdong Li   +3 more
openalex   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source