Results 81 to 90 of about 4,374,324 (311)
Fluid Bolus Therapy in Pediatric Sepsis: Current Knowledge and Future Direction
Frontiers in Pediatrics, 2018 Sepsis is a leading cause of morbidity and mortality in children with a worldwide prevalence in pediatric intensive care units of approximately 8%.
Ben Gelbart, Ben Gelbart, Ben Gelbart
doaj +1 more source
Neurological disease due to single gene defects represents a targetable entity for adeno-associated virus (AAV) mediated gene therapy. The delivery of AAV-mediated gene therapy to the brain is challenging, owing to the presence of the blood-brain barrier.
Vardar, Zeynep +6 more
core +1 more source
Fluid Therapy for the Bovine Patient
, 1983 The purpose of this presentation is to illustrate our use of fluid therapy on bovine patients. There will not be a detailed discussion on serum electrolyte and / or pH changes.
Mueller, Marc
core +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Four phases of intravenous fluid therapy: A conceptual model
, 2014 I.V. fluid therapy plays a fundamental role in the management of hospitalized patients. While the correct use of i.v. fluids can be lifesaving, recent literature demonstrates that fluid therapy is not without risks.
Hoste, AD
core +2 more sources
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Understanding Volume Kinetics: The Role of Pharmacokinetic Modeling and Analysis in Fluid Therapy
Frontiers in Veterinary Science, 2020 Fluid therapy is a rapidly evolving yet imprecise clinical practice based upon broad assumptions, species-to-species extrapolations, obsolete experimental evidence, and individual preferences. Although widely recognized as a mainstay therapy in human and
Xiu Ting Yiew +5 more
doaj +1 more source
Veterinary Clinics of North America: Small Animal Practice, 2017 Anesthesia can lead to pathophysiologic changes that dramatically alter the fluid balance of the body compartments and the intravascular space. Fluid administration can be monitored and evaluated using static and dynamic indexes. Guidelines for fluid rates during anesthesia begin with 3 mL/kg/h in cats and 5 mL/kg/h in dogs.
Lois Bates Acheson Veterinary Teaching Hospital, Oregon State University, Corvallis, OR, USA ( host institution ) +2 more
openaire +3 more sources
Fluid, electrolyte, and acid-base disorders in small animal practice /
, 2006 This comprehensive resource brings together cutting edge information about fluid, electrolyte, and acid-base physiology and fluid therapy as they apply to small animal practice. It also offers complete coverage of relevant physiology and pathophysiology,
DiBartola, Stephen P. +1 more
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source