Results 101 to 110 of about 1,090,687 (302)

Investigating the effectiveness of an intraoperative decision support guided fluid therapy intervention on postoperative outcome of high-risk patients undergoing high-risk abdominal surgery: protocol for an international multicentre stepped-wedge cluster-randomised implementation trial

BJA Open
Background: Inappropriate fluid administration can impact patient outcome. Intraoperative advanced haemodynamic monitoring coupled with a treatment protocol based on stroke volume optimisation can help determine the appropriate timing for fluid boluses ...
Sean Coeckelenbergh, Amelie Delaporte, Damien Rousseleau, Jacques De Montblanc, Stephanie Roullet, Joanna Ramadan, Bernard Cholley, Alexandre Stibon, Emmanuel Weiss, Maria-Christina Kassab, Sylvain Diop, Elsa Manzi, Marco Pustetto, Guillaume Porta Bonette, Pierre Gregoire Guinot, Philippe Guerci, Domien Vanhonacker, Francois Martin Carrier, Brenton Alexander, Joseph Rinehart, David Boldt, Tristan Grogan, Maxime Cannesson, Jacques Duranteau, Lamiae Grimaldi, Bruno Pereira, Alexandre Joosten   +26 more
doaj   +1 more source

Hidratação com bicarbonato de sódio não previne a nefropatia de contraste: ensaio clínico multicêntrico Hydration with sodium bicarbonate does not prevent contrast nephropathy: a multicenter clinical trial

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: A exposição ao meio de contraste radiográfico pode causar comprometimento agudo da função renal. Há evidências limitadas e conflitantes de que a hidratação com bicarbonato de sódio previne a Nefropatia Induzida por Contraste (NIC) em ...
Vitor O. Gomes, Ricardo Lasevitch, Valter C. Lima, Fábio S. Brito Jr., Juan Carlos Perez-Alva, Bruno Moulin, Airton Arruda, Denise Oliveira, Paulo Caramori   +8 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Control of the postoperative condition of cats with unilateral ureteral obstruction

RUDN Journal of Agronomy and Animal Industries
Treatment of acute postrenal ureteral obstruction is arather complicated, but extremely necessary process. It includes both surgical techniques to resolve the obstruction, and drug treatment, which largely affects the patients recovery period.
Vladislav A. Lust, Grigory E. Scheidt
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Pulse pressure variation and pleth variability index as predictors of fluid responsiveness in patients undergoing spinal surgery in the prone position

Therapeutics and Clinical Risk Management, 2018
Do-Hyeong Kim,1 Seokyung Shin,1 Ji Young Kim,1 Seung Hyun Kim,2 Minju Jo,2 Yong Seon Choi1 1Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea ...
Kim DH, Shin S, Kim JY, Kim SH, Jo M, Choi YS   +5 more
doaj  

Fluidoterapia en Neurocirugía Craneal

Revista Electrónica de AnestesiaR, 1970
La fluidoterapia junto a la hipnosis, la protección neurovegetativa, el alivio del dolor y el mantenimiento de un adecuado bloqueo neuromuscular es uno de los pilares fundamentales de la práctica anestésica. Valorar las necesidades hídricas es un difícil
Helena Benito Naverac
doaj   +1 more source

Maintenance of head and neck tumor on-chip: gateway to personalized treatment? [PDF]

, 2017
Aim: Head and neck squamous cell carcinomas (HNSCC) are solid tumors with low overall survival (40–60%). In a move toward personalized medicine, maintenance of tumor biopsies in microfluidic tissue culture devices is being developed. Methodology/ results:
Bower, Ruth, Crank, Stephen T, Green, Victoria L., Greenman, John, Karsai, Laszlo, Kuvshinov, Dmitriy, Kuvshinova, Elena, Stafford, Nicholas D   +7 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Prognostic robustness of serum creatinine based AKI definitions in patients with sepsis: a prospective cohort study [PDF]

, 2015
Background: It is unclear how modifications in the way to calculate serum creatinine (sCr) increase and in the cut-off value applied, influences the prognostic value of Acute Kidney Injury (AKI).
Dhondt, Annemieke, Lameire, Norbert, Van Biesen, Wim, Vanholder, Raymond, Vanmassenhove, Jill   +4 more
core   +2 more sources