Results 81 to 90 of about 594,017 (304)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Effects of an Iso‐Osmotic Chloride‐Free Solution With High Strong Ion Difference vs. Ringer's Lactate on Non‐Lactate Metabolic Acidosis in Dogs

Journal of Veterinary Internal Medicine
Background Metabolic acidosis is a common acid–base disorder in critically ill dogs, with fluid therapy being a key but debated treatment. Sodium bicarbonate's risks have spurred interest in safer alternatives such as sodium lactate.
Roberto Rabozzi, Stefano Oricco
doaj   +1 more source

Clinical and immunological monitoring of gingival fluid cytokines in patients with perimplantitis during photodynamic therapy

, 2020
Е. В. Ипполитов, S. T. Ilyasova, G. J. Akhmedov, A. V. Arutyunyan, В.Н. Царев   +4 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Hidratação enteral em equinos - solução eletrolítica associada ou não à glicose, à maltodextrina e ao sulfato de magnésio: resultados de laboratório Enteral fluid therapy in horses - electrolyte solution associated or not with glucose, maltodextrine and magnesium sulphate: laboratory results

Ciência Rural, 2009
No presente estudo, foram avaliados os efeitos de soluções eletrolíticas administradas via sonda nasoesofágica de pequeno calibre sobre o hematócrito, o volume plasmático e as concentrações plasmáticas de proteínas totais, sódio, potássio, cloreto ...
Marcel Ferreira Bastos Avanza, José Dantas Ribeiro Filho, Marco Aurélio Ferreira Lopes, Fernanda Saules Ignácio, Thony Assis Carvalho, José Domingos Guimarães   +5 more
doaj  

Study Protocol for Better Evidence for Selecting Transplant Fluids (BEST-Fluids): a pragmatic, registry-based, multi-center, double-blind, randomized controlled trial evaluating the effect of intravenous fluid therapy with Plasma-Lyte 148 versus 0.9% saline on delayed graft function in deceased donor kidney transplantation [PDF]

, 2020
Michael G. Collins, Magid Fahim, Elaine M. Pascoe, Kathryn Dansie, Carmel M. Hawley, Philip A. Clayton, Kirsten Howard, David W. Johnson, Colin McArthur, Rachael McConnochie, Peter F. Mount, Donna Reidlinger, Laura Robison, Julie Varghese, Liza A. Vergara, Laurence Weinberg, Steven J. Chadban, for the BEST-Fluids Investigators and the Australasian Kidney Trials Network   +17 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Effect of intraoperative fluid volume on postoperative pulmonary complications in thoracic surgeries: A systematic review and meta-analysis

Indian Journal of Anaesthesia
Background and Aims: There is a lack of clear recommendations on fluid strategies in patients undergoing thoracic surgeries. The primary objective of this study was to compare the amount of intraoperative intravenous fluid (IVF) infused between those who
Shreya Das Adhikari, Nitin Gupta, Mukund Gupta, Savan K. Nagesh, Souvik Chaudhuri, Rakesh Garg   +5 more
doaj   +1 more source

Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group [PDF]

, 2004
Rinaldo Bellomo, Claudio Ronco, John A. Kellum, Ravindra L. Mehta, Paul M. Palevsky, the ADQI workgroup   +5 more
openalex   +1 more source