Results 61 to 70 of about 503,914 (338)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

GAMBARAN TINGKAT PENGETAHUAN TENTANG FLUOR ALBUS PADA SISWI KELAS X DAN XI DI SMA KARTIKA IV-3 SURABAYA [PDF]

, 2013
Munculnya fluor albus merupakan masalah yang sering muncul di kalangan remaja (11-19). Terdapat beberapa remaja yang sering mengeluh gatal sehingga merasa risih dengan adanya fluor albus tersebut.
YUANITA, YOLA
core  

The Roles of Membrane Rafts in CD32A-Mediated Phagocytosis [PDF]

, 2007
Membrane rafts are highly dynamic heterogeneous sterol- and sphingolipid-rich micro-domains on cell surfaces. They are generally believed to provide residency for cell surface molecules (e.g., adhesion and signaling molecules) and scaffolding to ...
Cheng Zhu, Periasamy Selvaraj, Timothy P. Tolentino   +2 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

HUBUNGAN PERILAKU VULVA HYGIENE DENGAN KEJADIAN FLUOR ALBUS PADA REMAJA PUTRI DI SMA UNGGULAN AMANATUL UMMAH SURABAYA [PDF]

, 2017
Perilaku kesehatan reproduksi yang kurang masih banyak ditemukan pada remaja putri, terutama dalam menjaga kesehatan organ reproduksi serta pemahaman yang kurang akan vulva hygiene seperti perilaku cebok yang kurang benar ...
SAADAH, HANIFATUS
core  

Discerning Aggregation in Homogeneous Ensembles: A General Description of Photon Counting Spectroscopy in Diffusing Systems

, 2004
In order to discern aggregation in solutions, we present a quantum mechanical analog of the photon statistics from fluorescent molecules diffusing through a focused beam.
A. G. Palmer, Albert Libchaber, D. L. Snyder, E. L. Elson, Grégoire Altan-Bonnet, H. Qian, H. Qian, Hai-Cang Ren, J. Enderlein, K. Palo, L. Mandel, L. Mandel, L. Mandel, Noel L. Goddard, P. Kask, P. Kask, P. Schwille, R. P. Feynman, R. Rigler, Y. Chen   +19 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Induction of MET Receptor Tyrosine Kinase Down-Regulation through Antibody-Mediated Receptor Clustering [PDF]

, 2019
The proto-oncoprotein MET is a receptor tyrosine kinase that plays a key role in cancer cell growth and invasion. We have used fluorescence-tagged antibodies to activate MET in live serum-starved glioblastoma cells and monitor the fate of antibody-bound ...
Adam Dick, Fei Lu, Hong Sun, Hui Zhang, Wenjing Li   +4 more
core   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Biotransferencia de flúor de agua a diferentes tejidos de pejerrey (Odontesthes bonariensis)

Biología Acuática, 2014
La presencia de flúor (F), oligoelemento tóxico, tiene relevancia en la cadena trófica porque puede degradarse a diferentes niveles. Puede provenir del agua como alimento, siendo la ingestión crónica nociva para los seres humanos. El flúor se encontró en
María Laura Puntoriero, Alejandra V. Volpedo, Alicia Fernández Cirelli   +2 more
doaj