Results 181 to 190 of about 78,764 (278)

The Hypoxia‐Associated High‐Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma

open access: yesAdvanced Science, EarlyView.
This study suggests the potential roles of a novel hypoxia‐associated CDC20+KIF20A+PTTG1+ cell subpopulation in glioma progression. This high‐risk glioma cell subpopulation is therapeutically vulnerable to glioma progression and may play important roles in glioma standard‐of‐care therapeutic resistance.
Quan Wan   +13 more
wiley   +1 more source

Implanted Microneedles Loaded with Sparfloxacin and Zinc‐Manganese Sulfide Nanoparticles Activates Immunity for Postoperative Triple‐Negative Breast Cancer to Prevent Recurrence and Metastasis

open access: yesAdvanced Science, EarlyView.
Hyaluronic acid Microneedles (MNs) are loaded with Sparfloxacin (SP) and zinc‐manganese sulfide (ZMS) for the postoperative in situ treatment of triple‐negative breast cancer (TNBC) to prevent cancer recurrence and combat wound infection. These microneedles enhance antitumor immunity by activating the cGAS‐STING pathway, suppress tumor growth, reduce ...
Zhaoyou Chu   +8 more
wiley   +1 more source

Proteolysis Assays With Conserved or Aminofluorescein-Labeled Red Blood Cells. [PDF]

open access: yesBiomed Res Int
Al-Essa MK   +3 more
europepmc   +1 more source

Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

open access: yesAdvanced Science, EarlyView.
Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang   +13 more
wiley   +1 more source

Mitigating Cellular Dysfunction Through Contaminant Reduction in Synthetic circRNA for High‐Efficiency mRNA‐Based Cell Reprogramming

open access: yesAdvanced Science, EarlyView.
This study addresses the challenges of synthetic circular RNAimpurities that trigger immune responses and hinder efficacy. Key immunogenic byproducts are identified and develop a multi‐step purification process that produces ultra‐pure circRNA and enhances yields by over 10‐fold.
Ziwei Zhang   +7 more
wiley   +1 more source

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