Results 191 to 200 of about 78,764 (278)

ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation

Advanced Science, EarlyView.
RNA modification is crucial in fibrosis diseases, but the role of m1A modification remains elusive. This study reveals that ALKBH3, an m1A demethylase, drives skin fibrosis by reshaping m6A RNA modification and stabilizing COL1A1 and FN1 mRNAs through METTL3, uncovering a crosstalk between m1A and m6A methylation in pathological events.
Liying Tu, Shuchen Gu, Ruoqing Xu, En Yang, Xin Huang, Hsin Liang, Shenying Luo, Haizhou Li, Yixuan Zhao, Tao Zan   +9 more
wiley   +1 more source

Fluorescent labeling strategies for molecular bioimaging. [PDF]

Biophys Rep (N Y)
Streit M, Budiarta M, Jungblut M, Beliu G.   +3 more
europepmc   +1 more source

Natural Enzyme‐Loaded Polymeric Stealth Coating‐Armed Engineered Probiotics by Disrupting Tumor Lactate Homeostasis to Synergistic Metabolism‐Immuno‐Enzyme Dynamic Therapy

Advanced Science, EarlyView.
Engineered Lactobacillus acidophilus (LH@LA) is developed via in situ polymerization to co‐load lactate oxidase (LOx) and horseradish peroxidase (HRP). This system preserves LA activity, evades macrophage phagocytosis, and synergizes LA metabolism with enzyme cascades to enhance immunity, reduce tumor ATP, suppress PD‐L1 expression and AKT‐mTOR ...
Liuzhou Mao, Bahriman Xarpidin, Rui Shi, Yuting Lin, Haohua Hu, Caisheng Wu, Zheng Luo, Yun‐Long Wu   +7 more
wiley   +1 more source

Facile Synthesis of Pyridyl Rosamines as Potential Photosensitizers. [PDF]

Int J Mol Sci
Bakos É, Ágoston H, Ignácz R, Hunyadi A, Poór M, Erostyák J, Kele Z, Özvegy-Laczka C, Mernyák E.   +8 more
europepmc   +1 more source

Lactoflavin, eine Komponente des „Bakterien-Fluoresceins“

, 1948
L. Birkofer, Anneliese Birkofer
semanticscholar   +1 more source

Improved Orthogonality in Naphthalimide/Cyanine Dyad Boosts Superoxide Generation: a Tumor‐Targeted Type‐I Photosensitizer for Photodynamic Therapy of Tumor by Inducing Ferroptosis

Advanced Science, EarlyView.
A tumor‐targeted, renal‐metabolized, and less O2‐dependent Type‐I photosensitizer is presented for photodynamic therapy of tumors. The formation of an intramolecular sandwich‐like π–π assembly ensures its rigid orthogonal geometry, thereby improving the superoxide (O2•−)‐generating ability, promoting the intracellular formation of hydroxy radical (HO•),
Guangxiao Yao, Junfeng Miao, Yingying Huo, Wei Guo   +3 more
wiley   +1 more source

Visualization of bone formation in sheep's middle ear by using fluorochrome sequential labelling (FSL). [PDF]

Sci Rep
Kemper M, Kluge A, Ney M, Beleites T, Zeidler-Rentzsch I, Keil C, Zahnert T, Neudert M.   +7 more
europepmc   +1 more source

Enhanced the Trans‐Cleavage Activity of CRISPR‐Cas12a Using Metal‐Organic Frameworks as Stimulants for Efficient Electrochemical Sensing of Circulating Tumor DNA

Advanced Science, EarlyView.
This work designs manganese metal‐organic frameworks (Mn‐MOFs) co‐assembled with Cas12a/crRNA, enabling rapid release of Mn2⁺ under mild conditions. The MOFs‐induced proximity effect sustains Mn2⁺‐Cas12a/crRNA interactions, enhancing the trans‐cleavage activity of complex available to develop an electrochemical biosensor based on Mn‐MOFs‐enhanced ...
Shuai Wu, Yincheng Liu, Tianyu Zeng, Tianci Zhou, Yanting Sun, Ying Deng, Juan Zhang, Genxi Li, Yongmei Yin   +8 more
wiley   +1 more source

Microfluidic production, stability and loading of synthetic giant unilamellar vesicles. [PDF]

Sci Rep
Ernits M, Reinsalu O, Yandrapalli N, Kopanchuk S, Moradpur-Tari E, Sanka I, Scheler O, Rinken A, Kurg R, Kyritsakis A, Linko V, Zadin V.   +11 more
europepmc   +1 more source

Aqueous Two‐Phase Submicron Droplets Catalyze DNA Nanostructure Assembly for Confined Fluorescent Biosensing

Advanced Science, EarlyView.
Submicron droplets, formed by a polyethyleneglycol (PEG)/dextran aqueous two‐phase system·(ATPS), can act as catalytic centers that concentrate DNA and accelerate assembly kinetic in crowded environments. It highlights a cooperative mechanism wherein global crowding from PEG induces an excluded volume effect, while local crowding from dextran provides ...
Xiaoman Duan, Siyi Duan, Zhaoyu Han, Haoyue Lv, Haozhen Yu, Biwu Liu   +5 more
wiley   +1 more source