Results 211 to 220 of about 80,277 (338)

Compressed Cells Facilitate Adhesion Through Glycocalyx

open access: yesAdvanced Science, EarlyView.
This study quantifies how cell compression and confinement triggers cell adhesion. Under low compression, integrins dominate cell adhesion to extracellular matrix (ECM) proteins, whereas the glycocalyx contributes weak unspecific adhesion. With increasing compression, the glycocalyx increases its unspecific adhesion to ECM and non‐ECM proteins and can ...
Xiaole Wang   +3 more
wiley   +1 more source

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

open access: yesAdvanced Science, EarlyView.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz   +14 more
wiley   +1 more source

Visualization of bone formation in sheep's middle ear by using fluorochrome sequential labelling (FSL). [PDF]

open access: yesSci Rep
Kemper M   +7 more
europepmc   +1 more source

WSGC@FA@PEG/PEI‐SPIONs Mitigate Chemoresistance in Gastric Adenocarcinoma by Modulating the Notch Signaling Pathway and Mitophagy

open access: yesAdvanced Science, EarlyView.
WSGC peptide reverses drug resistance in GA by modulating the Notch signaling pathway and mitophagy at the molecular level. Abstract This study investigates the molecular mechanisms by which superparamagnetic iron oxide nanoparticles (SPIONs) loaded with the WSGC peptide (WSGC@FA@PEG/PEI‐SPIONs)—a 40‐amino acid polypeptide derived from apoC‐III ...
Dongjian Song   +10 more
wiley   +1 more source

Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang   +14 more
wiley   +1 more source

Covalently deposited dyes: a new chromogen paradigm that facilitates analysis of multiple biomarkers in situ

open access: yesLaboratory Investigation, 2017
W. Day   +11 more
semanticscholar   +1 more source

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