Results 141 to 150 of about 2,158,256 (257)

TMEM55B Maintains Lysosomal Homeostasis and Promotes ER-Lysosome Calcium Signaling. [PDF]

Traffic
Mukae N, Maki H, Shirane M.
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Heme sequestration and signaling in molecular condensates. [PDF]

Chem Sci
Mishra A, Gallio AE, Raven EL, Patil AJ, Mann S.   +4 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Multimodal Phasor Approach to Study Breast Cancer Cell Invasion in a 3D Spheroid Model

Chemical & Biomedical Imaging
Giulia Tedeschi, Francesco Palomba, Lorenzo Scipioni, Michelle A. Digman   +3 more
doaj   +1 more source

A label-free fluorescent sensor for miR-21 based on sequentially coupled CHA-HCR dual-stage amplification and synergistic signal regulation by graphene oxide and SYBR Green I. [PDF]

RSC Adv
Qiao C, Zhang Z, Sang Y, Hu M, Dong Y, Wang L.   +5 more
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Anion-specific fluorescence enhancement <i>via</i> counterion modulation in biphenyl-based porous cage salts. [PDF]

Chem Sci
Sabatino RM, Morey MN, Lovstedt A, Bloch ED.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Phosphate-Engineered DNA Reporters Boost CRISPR-Cas12a Trans-Cleavage for Rapid and Sensitive Nucleic Acid Detection. [PDF]

Adv Sci (Weinh)
Yang R, Guo C, Pei M, Zhang J, Guan X, Zhang S, Liu X, Schalper KT, Avery L, LaSala R, Banach D, Liu C.   +11 more
europepmc   +1 more source