Light-Switchable Membrane Permeability in Giant Unilamellar Vesicles [PDF]
Pharmaceutics, 2022 In this work, giant unilamellar vesicles (GUVs) were synthesized by blending the natural phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) with a photoswitchable amphiphile (1) that undergoes photoisomerization upon irradiation with UV-
Paola Albanese +6 more
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Effects of membrane potentials on the electroporation of giant unilamellar vesicles. [PDF]
PLoS ONE, 2023 Living organisms maintain a resting membrane potential, which plays an important role in various biophysical and biological processes. In the context of medical applications, irreversible electroporation (IRE) is a non-thermal and minimally invasive ...
Md Abdul Wadud +3 more
doaj +5 more sources
Molecules, 2022 Curcumin-loaded native and succinylated pea protein nanoparticles, as well as zwitterionic giant unilamellar vesicles were used in this study as model bioactive compound loaded-nanoparticles and biomembranes, respectively, to assess bio-nano interactions.
Chibuike C Udenigwe +2 more
exaly +4 more sources
A Practical Guide to Preparation and Applications of Giant Unilamellar Vesicles Formed via Centrifugation of Water-in-Oil Emulsion Droplets [PDF]
Membranes, 2023 Giant vesicles (GVs), which are closed lipid bilayer membranes with a diameter of more than 1 μm, have attracted attention not only as model cell membranes but also for the construction of artificial cells.
Yiting Zhang, Haruto Obuchi, Taro Toyota
doaj +3 more sources
Wrapping Pathways of Anisotropic Dumbbell Particles by Giant Unilamellar Vesicles. [PDF]
Nano Lett, 2023 Endocytosis is a key cellular process involved in the uptake of nutrients, pathogens, or the therapy of diseases. Most studies have focused on spherical objects, whereas biologically relevant shapes can be highly anisotropic.
Azadbakht A +4 more
europepmc +8 more sources
Microfluidic production, stability and loading of synthetic giant unilamellar vesicles [PDF]
Scientific ReportsIn advanced drug delivery, versatile liposomal formulations are commonly employed for safer and more accurate therapies. Here we report a method that allows a straightforward production of synthetic monodisperse (~ 100 μm) giant unilamellar vesicles ...
Mart Ernits +11 more
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Surfactant-free production of biomimetic giant unilamellar vesicles using PDMS-based microfluidics
Communications Chemistry, 2021 The production of giant unilamellar vesicles by microfluidics commonly involves additives, which may interfere with the resultant membrane properties. Here pure lipid GUVs are prepared which exclude residual surfactants and other additives.
Naresh Yandrapalli +3 more
doaj +2 more sources
Measuring Encapsulation Efficiency in Cell-Mimicking Giant Unilamellar Vesicles. [PDF]
ACS Synth Biol, 2023 One of the main drivers within the field of bottom-up synthetic biology is to develop artificial chemical machines, perhaps even living systems, that have programmable functionality.
Supramaniam P +7 more
europepmc +2 more sources
Thermal fluctuations of the lipid membrane determine particle uptake into Giant Unilamellar Vesicles. [PDF]
Nat Commun, 2023 Particulates, bacteria and viruses wrap into cell membranes. Here the authors use optical tweezers, particle tracking and mathematical modelling to show that the uptake process into giant vesicles is influenced by thermal membrane fluctuations ...
Ayala YA +3 more
europepmc +2 more sources
Artificial cells with viscoadaptive behavior based on hydrogel-loaded giant unilamellar vesicles. [PDF]
Chem Sci, 2023 Viscoadaptation is an essential process in natural cells, where supramolecular interactions between cytosolic components drive adaptation of the cellular mechanical features to regulate metabolic function.
Llopis-Lorente A +5 more
europepmc +2 more sources