Results 151 to 160 of about 3,713,947 (387)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Confocal laser scanning microscopy reveals species-specific differences in distribution of fluorescent proteins in coral tissues

open access: yesFrontiers in Marine Science
Reef-building corals have a variety of green fluorescent protein (GFP)-like proteins, also known as fluorescent proteins (FPs). These proteins have broad spectral properties covering most of the visible spectrum, with fluorophores fluorescing from cyan ...
Giulia M. Marchioro   +13 more
doaj   +1 more source

Use of nuclepore filters for counting bacteria by fluorescence microscopy

open access: yesApplied and Environmental Microbiology, 1977
J. Hobbie, R. Daley, S. Jasper
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

OH(A-X) fluorescence from photodissociative excitation of HO2 at 157.5 nm [PDF]

open access: yes
The OH(A-X) fluorescence from photodissociative excitation of HO2 by F2 laser photons (157.5 nm) was observed and compared with the OH fluorescence spectra of H2O2 and the O2+CH3OH mixture.
Lee, L. C.   +3 more
core   +1 more source

Highly efficient multi-resonance thermally activated delayed fluorescence material toward a BT.2020 deep-blue emitter [PDF]

open access: gold
Junki Ochi   +7 more
openalex   +1 more source

Single molecule tracking fluorescence microscopy in mitochondria reveals highly dynamic but confined movement of Tom40 [PDF]

open access: gold, 2011
Anton Kuzmenko   +7 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Ultra-high resolution imaging by fluorescence photoactivation localization microscopy.

open access: yesBiophysical Journal, 2006
S. Hess   +2 more
semanticscholar   +1 more source

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