IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Biomass based carbon quantum dots in sensor applications: a review (2021-2025). [PDF]
Berdimurodov E +11 more
europepmc +1 more source
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
A novel antiviral strategy targeting human metapneumovirus through pH modulation in human airway epithelial cells. [PDF]
Daniels IA +8 more
europepmc +1 more source
Effect of terahertz irradiation on DNA damage repair in living cells
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
wiley +1 more source
Protocol for covalent RNA labeling by RiboLight dyes for detection by in-gel fluorescence and fluorescence microscopy. [PDF]
Kim MJ, Shin J, Kool ET.
europepmc +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Multipurpose Sensor Based on a Polymethacrylate Matrix Nanocomposite with Immobilized Gold Nanoparticles for the Determination of Environmental Pollutants. [PDF]
Kuznetsova DE +4 more
europepmc +1 more source
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source
Angle-Dependent Dip Coating Strategy for Silver Nanostructured Surface Fabrication with Enhanced Fluorescence and Surface-Enhanced Raman Scattering Properties. [PDF]
Qi L, Guo K, Ning X, Huang Y, Lu X.
europepmc +1 more source

