Results 191 to 200 of about 1,945,444 (315)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Analysis of lipid-assisted self-assembly of hydrophobic CuInS₂/ZnS quantum dots into water-stable nanoclusters that perform intra-cluster energy transfer.

Nanoscale
Whipp JT, Hancock AM, Aslam Z, Critchley K, Adams PG.   +4 more
europepmc   +1 more source

A single-vesicle fluorescence microscopy platform to quantify phospholipid scrambling. [PDF]

Nat Struct Mol Biol
Veit S, Dearden GI, Menon KM, Noor F, Menon I, Morizumi T, Ernst OP, Menon AK, Pomorski TG.   +8 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

The contribution of the ²⁴⁰Ala:Glu:Glu:Thr²⁴³ sequence in the DE-loop of D2 to the acceptor side of Photosystem II. [PDF]

Photosynth Res
Khaing EP, Summerfield TC, Forsman JA, Vass I, Patil PP, Eaton-Rye JJ.   +5 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Microviscosity-gated excited-state partitioning in a NIR-II molecular rotor for disease imaging and imaging-guided photothermal therapy. [PDF]

Mater Today Bio
Qin Y, You Y, Yu Y, Xie Y, Sha Y, Feng J, Zeng Y, Zhang J, Lei Z, Lu C, Fang M, Cui M, Zhou K.   +12 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Experimental Evaluation of Fecal-Mediated Transfer of <i>Salmonella</i> Typhi From <i>Blattella germanica</i> to Mice. [PDF]

J Trop Med
Geng DF, Zhao T, Liu XH, Zhang RX, Yu HT, Chen XL, Xing D, Wu JH, Li CX.   +8 more
europepmc   +1 more source