Results 61 to 70 of about 3,604,557 (398)

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Metabolic fingerprinting of bacteria by fluorescence lifetime imaging microscopy

Scientific Reports, 2017
Bacterial populations exhibit a range of metabolic states influenced by their environment, intra- and interspecies interactions. The identification of bacterial metabolic states and transitions between them in their native environment promises to ...
Arunima Bhattacharjee, Rupsa Datta, Enrico Gratton, Allon I. Hochbaum   +3 more
doaj   +1 more source

Eph/ephrins mediated thymocyte-thymic epithelial cell interactions control numerous processes of thymus biology

Frontiers in Immunology, 2015
Numerous studies emphasize the relevance of thymocyte-thymic epithelial cell (TECs) interactions for the functional maturation of intrathymic T lymphocytes.
Javier eGarcia-Ceca, David eAlfaro, Sara eMontero-Herradón, Esther eTobajas, Juan José Muñoz, Agustin G Zapata, Agustin G Zapata   +6 more
doaj   +1 more source

Visible light-induced switching of soft matter materials properties based on thioindigo photoswitches

Nature Communications, 2023
Thioindigos are visible light responsive photoswitches with excellent spatial control over the conformational change between their trans- and cis- isomers.
Sarah L. Walden, Phuong H. D. Nguyen, Hao-Kai Li, Xiaogang Liu, Minh T. N. Le, Loh Xian Jun, Christopher Barner-Kowollik, Vinh X. Truong   +7 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Endosomal H₂O₂ Molecules Act as Signaling Mediators in Akt/PKB Activation

Antioxidants
Receptor-mediated endocytosis (RME) is a commonly recognized receptor internalization process of receptor degradation or recycling. However, recent studies have supported that RME is closely related to signal propagation and amplification from the plasma
Sujin Park, Chaewon Kim, Sukyeong Heo, Dongmin Kang   +3 more
doaj   +1 more source

No Difference in Myosin Kinetics and Spatial Distribution of the Lever Arm in the Left and Right Ventricles of Human Hearts

Frontiers in Physiology, 2017
The systemic circulation offers larger resistance to the blood flow than the pulmonary system. Consequently, the left ventricle (LV) must pump blood with more force than the right ventricle (RV). The question arises whether the stronger pumping action of
Divya Duggal, S. Requena, Janhavi Nagwekar, Sangram Raut, Ryan Rich, Hriday Das, Vipul Patel, Vipul Patel, Ignacy Gryczynski, Rafal Fudala, Zygmunt Gryczynski, Cheavar Blair, Kenneth S. Campbell, Julian Borejdo   +13 more
doaj   +1 more source

Porous Si Microparticles Infiltrated with Magnetic Nanospheres

Nanomaterials, 2020
Porous silicon (pSi) microparticles obtained by porosification of crystalline silicon wafers have unique optical properties that, together with biodegradability, biocompatibility and absence of immunogenicity, are fundamental characteristics to candidate
Elena Chistè, Gloria Ischia, Marco Gerosa, Pasquina Marzola, Marina Scarpa, Nicola Daldosso   +5 more
doaj   +1 more source

Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents.

Chemical Society Reviews, 2018
In this review we will explore recent advances in the design and application of excited-state intramolecular proton-transfer (ESIPT) based fluorescent probes.
A. Sedgwick, Luling Wu, Hai-Hao Han, S. Bull, Xiao‐Peng He, T. James, J. Sessler, B. Tang, H. Tian, Juyoung Yoon   +9 more
semanticscholar   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source