Results 71 to 80 of about 2,110,693 (302)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Fluorescence Lifetime of PDT Photosensitizers [PDF]

open access: yes, 2008
Photodynamic therapy (PDn is an effective treatment option for various types of invasive tumors, the efficacy of which depends strongly on selective cell uptake and selective excitation of the tumor, which relies on proper dosage.
Russell, Jennifer
core  

Red-Shifted FRET Biosensors for High-Throughput Fluorescence Lifetime Screening

open access: yesBiosensors, 2018
We have developed fluorescence resonance energy transfer (FRET) biosensors with red-shifted fluorescent proteins (FP), yielding improved characteristics for time-resolved (lifetime) fluorescence measurements.
Tory M. Schaaf   +9 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

A study on the conversion of carotene into vitamin A by fluorescence microphotometry [PDF]

open access: yes, 1971
For the purpose to confirm whether carotene is converted into vitamin A mainly in the intestine, fluorescence microscope observations as well as the fluorescence microphotometry for the estimation of fading state of the fluorescence were carried out on ...
Iimori, Saburo
core   +1 more source

In Vivo Single-Cell Detection of Metabolic Oscillations in Stem Cells

open access: yesCell Reports, 2015
Through the use of bulk measurements in metabolic organs, the circadian clock was shown to play roles in organismal energy homeostasis. However, the relationship between metabolic and circadian oscillations has not been studied in vivo at a single-cell ...
Chiara Stringari   +7 more
doaj   +1 more source

BMAL1 Associates with NOP58 in the Nucleolus and Contributes to Pre-rRNA Processing

open access: yesiScience, 2020
Summary: The transcription factor BMAL1 is a core element of the circadian clock that contributes to cyclic control of genes transcribed by RNA polymerase II.
Marlene Cervantes   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Direct Detection and Quantification of Aqueous Proteins via a Fluorescent Probe Through the Use of Fluorophore-Induced Plasmonic Current

open access: yesBiosensors
We report on the recent advancements in the sensing of proteins, both directly and with the use of a fluorescent probe, through the use of Fluorophore-Induced Plasmonic Current (FIPC). FIPC are a phenomenon where a fluorophore or excited state species is
Daniel R. Pierce, Chris D. Geddes
doaj   +1 more source

Waste packaging polymeric foam for oil-water separation: An environmental remediation

open access: yesData in Brief, 2018
Nowadays, its urgent need to develop and fabricate efficient, low cost, eco-friendly, oil-water separation methodologies especially for variety of polluted water in the environments.
Chandrashekhar S. Patil   +5 more
doaj   +1 more source

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