Results 41 to 50 of about 1,475,531 (219)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Studies on glucose detection using graphene quantum dots prepared by hydrothermal method

Scientific Reports
The increasing number of diabetic patients is a critical global challenge and monitoring of glucose level in blood via simple technique is of great importance.
Swapnali P. Rajmane, Omkar S. Nille, G. B. Kolekar, Shivaji B. Sadale   +3 more
doaj   +1 more source

Metabolic fingerprinting of bacteria by fluorescence lifetime imaging microscopy

Scientific Reports, 2017
Bacterial populations exhibit a range of metabolic states influenced by their environment, intra- and interspecies interactions. The identification of bacterial metabolic states and transitions between them in their native environment promises to ...
Arunima Bhattacharjee, Rupsa Datta, Enrico Gratton, Allon I. Hochbaum   +3 more
doaj   +1 more source

No Difference in Myosin Kinetics and Spatial Distribution of the Lever Arm in the Left and Right Ventricles of Human Hearts

Frontiers in Physiology, 2017
The systemic circulation offers larger resistance to the blood flow than the pulmonary system. Consequently, the left ventricle (LV) must pump blood with more force than the right ventricle (RV). The question arises whether the stronger pumping action of
Divya Duggal, S. Requena, Janhavi Nagwekar, Sangram Raut, Ryan Rich, Hriday Das, Vipul Patel, Vipul Patel, Ignacy Gryczynski, Rafal Fudala, Zygmunt Gryczynski, Cheavar Blair, Kenneth S. Campbell, Julian Borejdo   +13 more
doaj   +1 more source

Dataset on the shooting and rooting ability of Morus alba using waste tea residue derived carbon dots as an alternative of growth plant stimulator

Data in Brief, 2020
The data article ex vitro (vegetative plant propagation) culture techniques are sustainable alternatives to the large-scale production of economically important plant species.
Ravindra D. Waghmare, Anil H. Gore, P.V. Anbhule, Daewon Sohn, Govind B. Kolekar   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Visible light-induced switching of soft matter materials properties based on thioindigo photoswitches

Nature Communications, 2023
Thioindigos are visible light responsive photoswitches with excellent spatial control over the conformational change between their trans- and cis- isomers.
Sarah L. Walden, Phuong H. D. Nguyen, Hao-Kai Li, Xiaogang Liu, Minh T. N. Le, Loh Xian Jun, Christopher Barner-Kowollik, Vinh X. Truong   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Porous Si Microparticles Infiltrated with Magnetic Nanospheres

Nanomaterials, 2020
Porous silicon (pSi) microparticles obtained by porosification of crystalline silicon wafers have unique optical properties that, together with biodegradability, biocompatibility and absence of immunogenicity, are fundamental characteristics to candidate
Elena Chistè, Gloria Ischia, Marco Gerosa, Pasquina Marzola, Marina Scarpa, Nicola Daldosso   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source