Results 41 to 50 of about 3,402,841 (337)

Small-molecule fluorescence-based probes for interrogating major organ diseases.

Chemical Society Reviews, 2021
Chemical tools that allow the real-time monitoring of organ function and the visualisation of organ-related processes at the cellular level are of great importance in biological research.
Hai-Hao Han, H. Tian, Yi Zang, Adam C. Sedgwick, Jia Li, J. Sessler, Xiao-Peng He, Tony D. James   +7 more
semanticscholar   +1 more source

Fluorescent probes of the orientation of myosin regulatory light chains in relaxed, rigor, and contracting muscle. [PDF]

, 1996
The orientation of the light-chain region of myosin heads in relaxed, rigor, and isometrically contracting fibers from rabbit psoas muscle was studied by fluorescence polarization. Cysteine 108 of chicken gizzard myosin regulatory light chain (cgRLC) was
Shrimpton, C., Kendrick-Jones, J., Irving, M., Sleep, J., John Kendrick-jones, Ling, N., Carolyn Shrimpton, Ling, Nicholas, Malcolm Irvingt, Nicholas Ling, John Sleep   +10 more
core   +1 more source

Antioxidants as Molecular Probes: Structurally Novel Dihydro-m-Terphenyls as Turn-On Fluorescence Chemodosimeters for Biologically Relevant Oxidants

Antioxidants, 2020
One interesting aspect of antioxidant organic molecules is their use as probes for the detection and quantitation of biologically relevant reactive oxidant species (ROS).
Víctor González-Ruiz, Jegathalaprathaban Rajesh, Ana I. Olives, Damiano Rocchi, Jorge Gómez-Carpintero, Juan F. González, Vellaisamy Sridharan, M. Antonia Martín, J. Carlos Menéndez   +8 more
doaj   +1 more source

L-Lysine-Linked Modular Fluorescent Cholesteryl Mimics: Biophysical Properties, Molecular Interactions, and Cellular Applications

Sci
Fluorescent cholesterol probes are indispensable tools for studying membrane structure, dynamics, and trafficking. To better understand the structure–function relationship of fluorescent cholesteryl probes, we developed a series of five new modular ...
Nicholas McInchak, Laura Stawikowska, Haylee Mesa, Jonathan Meade, Qi Zhang, Maciej J. Stawikowski   +5 more
doaj   +1 more source

Linear approaches to intramolecular Förster Resonance Energy Transfer probe measurements for quantitative modeling [PDF]

, 2011
Numerous unimolecular, genetically-encoded Forster Resonance Energy Transfer (FRET) probes for monitoring biochemical activities in live cells have been developed over the past decade.
Kurt I. Anderson, Kida, K., Katarzyna Kida, Birtwistle, M.R., Kriegsheim, Alexander von, Anderson, K.I., Kida Katarzyna, von Kriegsheim, A., Walter Kolch, Anderson Kurt I., Kida, Katarzyna, Schwarz, J.P., Marc R Birtwistle, Birtwistle Marc R., Birtwistle, Marc R., Alexander von Kriegsheim, Kurt I Anderson, von Kriegsheim Alexander, Juliane P Schwarz, Schwarz Juliane P., Kolch, W., Marc R. Birtwistle, Kolch Walter, Juliane P. Schwarz, et al.   +24 more
core   +1 more source

Fluorescence imaging of drug target proteins using chemical probes

Journal of Pharmaceutical Analysis, 2020
Fluorescence imaging can provide valuable information on the expression, distribution, and activity of drug target proteins. Chemical probes are useful small-molecule tools for fluorescence imaging with high structural flexibility and biocompatibility ...
Hao Zhu, Itaru Hamachi
doaj   +1 more source

Activatable molecular fluorescence probes for the imaging and detection of ischemic stroke

Brain Science Advances, 2023
The real-time, noninvasive, nonionizing, high spatiotemporal resolution, and flexibility characteristics of molecular fluorescence imaging provide a uniquely powerful approach to imaging and monitoring the physiology and pathophysiology of ischemic ...
Mengdie Wang, Yan Zhang
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Use of a Multiplexed CMOS Microarray to Optimize and Compare Oligonucleotide Binding to DNA Probes Synthesized or Immobilized on Individual Electrodes

Sensors, 2010
The CombiMatrix microarray with 12,544 electrodes supports in situ electrochemical synthesis of user-defined DNA probes. As an alternative, we immobilized commercially synthesized DNA probes on individual electrodes coated with electropolymerized ...
David Danley, Wanda Lyon, John Cooper, Jodi Wilmoth, Nina Yazvenko, Karl Maurer   +5 more
doaj   +1 more source

Dual Probes for Positron Emission Tomography (PET) and Fluorescence Imaging (FI) of Cancer

Pharmaceutics, 2022
Dual probes that possess positron emission tomography (PET) and fluorescence imaging (FI) capabilities are precision medicine tools that can be used to improve patient care and outcomes. Detecting tumor lesions using PET, an extremely sensitive technique,
Richard Yuen, Frederick G. West, Frank Wuest   +2 more
doaj   +1 more source