Results 121 to 130 of about 55,338 (292)
Chromatin Dynamics during Lytic Infection with Herpes Simplex Virus 1
Viruses, 2013 Latent HSV-1 genomes are chromatinized with silencing marks. Since 2004, however, there has been an apparent inconsistency in the studies of the chromatinization of the HSV-1 genomes in lytically infected cells.
Luis M. Schang, Kristen L. Conn
doaj +1 more source
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Revealing the Effects of Nanoscale Membrane Curvature on Lipid Mobility
Membranes, 2017 Recent advances in nanoengineering and super-resolution microscopy have enabled new capabilities for creating and observing membrane curvature. However, the effects of curvature on single-lipid diffusion have yet to be revealed. The simulations presented
Abir Maarouf Kabbani +2 more
doaj +1 more source
Multiplexed in-gel microfluidic immunoassays: characterizing protein target loss during reprobing of benzophenone-modified hydrogels. [PDF]
, 2019 From whole tissues to single-cell lysate, heterogeneous immunoassays are widely utilized for analysis of protein targets in complex biospecimens. Recently, benzophenone-functionalized hydrogel scaffolds have been used to immobilize target protein for ...
Gopal, Anjali, Herr, Amy E
core +1 more source
Advanced Science, EarlyView.This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao +7 more
wiley +1 more source
Advanced Science, EarlyView.Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji +13 more
wiley +1 more source
A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application
Advanced Science, EarlyView.This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu +5 more
wiley +1 more source
Aggregation‐State Dynamics Drive Double Cooperativity Between Antimicrobial Peptides LL‐37 and HNP1
Angewandte Chemie, EarlyView.The double cooperative effect between LL‐37 and HNP1 arises from dynamic changes in their aggregation state. These LL‐37/HNP1 assemblies reorganize in a target‐dependent manner, suppressing activity toward mammalian cells while enabling potent antibacterial action.
Yuge Hou +9 more
wiley +2 more sources
Anomalous transport in the crowded world of biological cells
, 2013 A ubiquitous observation in cell biology is that diffusion of macromolecules and organelles is anomalous, and a description simply based on the conventional diffusion equation with diffusion constants measured in dilute solution fails.
Franosch, Thomas, Höfling, Felix
core +1 more source
Expanding the applicability of multiphoton fluorescence recovery after photobleaching by incorporating shear stress in laminar flow. [PDF]
J Biomed Opt, 2023 Elias TM, Brown EB, Brown EB.
europepmc +1 more source