Results 231 to 240 of about 40,790 (312)
All-optical strategies to minimize photobleaching in reversibly switchable fluorescent proteins. [PDF]
Nat CommunMarín-Aguilera G +8 more
europepmc +1 more source
A deep learning‐enabled toolkit for the 3D segmentation of ventricular cardiomyocytes
The Journal of Physiology, EarlyView.Abstract figure legend 3D cardiomyocyte segmentation enables comprehensive analyses of myocardial microstructure in health and disease; however, it is technically demanding. We present an open‐source toolkit for this task, which reduces challenges associated with sample preparation, image restoration, segmentation and proofreading.
Joachim Greiner +6 more
wiley +1 more source
Emergent Chemical Reactivity and Complexity of RNA Condensates
Angewandte Chemie, Volume 137, Issue 52, December 22, 2025.RNA condensates capable of substrate enrichment and catalysis modulate their environment. Could this start a catalytic selection loop or evolution? Abstract The RNA world hypothesis posits the existence of life‐like assemblies that consisted mostly of RNA.
Samuel Hauf +4 more
wiley +2 more sources
PolyQ Expansion Controls Biomolecular Condensation and Aggregation of the N-Terminal Fragments of Ataxin-2. [PDF]
Int J Mol SciLiu YH, Duan HT, Jiang LL, Hu HY.
europepmc +1 more source
Selection of Host Plasma Membrane Lipids by HIV‐1 Gag Protein
BioEssays, Volume 48, Issue 1, January 2026.Enrichment of sphingomyelin in the HIV‐1 envelope arises from Gag binding to PI(4,5)P2, which triggers reorganization of plasma membrane sphingomyelin/cholesterol domains through unknown mechanisms. We propose that cholesterol‐mediated interleaflet coupling between sphingomyelin and PI(4,5)P2, rather than interdigitation, underlies Gag‐induced lipid ...
Nario Tomishige +2 more
wiley +1 more source
Flow Cytometry: Advances, Challenges and Trends
BioEssays, Volume 48, Issue 1, January 2026.Recent advances in flow cytometry span hardware, data processing, and AI‐driven analytics. Emerging modalitiesincluding spectral, imaging, mass, and nano/EV cytometryenable higher‐parameter and small‐particle detection. Integrated machine learning drives a shift from manual gating toward automated multi‐omics workflows.
J. Paul Robinson +2 more
wiley +1 more source
Protein Science, Volume 35, Issue 1, January 2026.Abstract Curli, which are the major proteinaceous components of the Escherichia coli biofilm extracellular matrix, help protect cells against environmental stressors, including dehydration and antibiotics. Composed of the amyloid proteins CsgA and CsgB, curli self‐assemble as these protomers are secreted into the extracellular space.
Daniel J. Foust +5 more
wiley +1 more source
A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells
Angewandte Chemie, Volume 137, Issue 50, December 8, 2025.Photoswitchable fluorophores are critical for advanced bioimaging. Here, we develop a photoswitchable self‐labeling HaloTag that can reversibly modulate the emission of a bound fluorogenic dye via a light‐induced conformational change. In living cells, this tunable chemigenetic system enables precise spatiotemporal activation and control of emitter ...
Franziska Walterspiel +10 more
wiley +2 more sources