Results 131 to 140 of about 416,920 (380)

FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes

open access: yesFEBS Open Bio, EarlyView.
FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang   +5 more
wiley   +1 more source

Antibody Microarray for E. coli O157:H7 and Shiga Toxin in Microtiter Plates

open access: yesSensors, 2015
Antibody microarray is a powerful analytical technique because of its inherent ability to simultaneously discriminate and measure numerous analytes, therefore making the technique conducive to both the multiplexed detection and identification of ...
Andrew G. Gehring   +7 more
doaj   +1 more source

Measurement of Antibodies to Machupo Virus by the Indirect Fluorescent Technique

open access: yesExperimental Biology and Medicine, 1973
Bolivian hemorrhagic fever (BHF) was first recognized in the Province of Beni, Bolivia, in 1959 (1), and cases have continued to occur since then. Recent outbreaks have confirmed the fact that clinical manifestations can be quite nonspecific. Laboratory diagnosis is handicapped by a scarcity of facilities in the endemic region, as well as by the hazard
Karl M. Johnson, Peters Cj, Webb Pa
openaire   +3 more sources

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

open access: yesFEBS Open Bio, EarlyView.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

open access: yesFEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Cellular delivery of antibodies: effective targeted subcellular imaging and new therapeutic tool [PDF]

open access: yes, 2010
It is already more than a century since the pioneering work of the Nobel Laureate Ehrlich gave birth to the side chain theory1, which helped to define antibodies and their ability to target specific biological sites.
Andrew L. Lewis   +6 more
core   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

open access: yesFEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian   +6 more
wiley   +1 more source

Imaging the developing human external and internal urogenital organs with light sheet fluorescence microscopy. [PDF]

open access: yes, 2020
Technological advances in three-dimensional (3D) reconstruction techniques have previously enabled paradigm shifts in our understanding of human embryonic and fetal development. Light sheet fluorescence microscopy (LSFM) is a recently-developed technique
Baskin, Laurence   +9 more
core  

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

open access: yesFEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo   +11 more
wiley   +1 more source

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