Results 101 to 110 of about 318,895 (308)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Synthesis of Zeolite A from Bangka Kaolin as a High-Performance Host for Fluorescent Compounds [PDF]

open access: yesEPJ Web of Conferences
This study aimed to synthesize Zeolite A from Bangka kaolin and evaluate its potential as a high-performance host material for fluorescent compounds in latent fingerprint identification.
Rahman Arif   +4 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Brewing yeast viability measured using a novel fluorescent dye and image cytometer

open access: yesBiotechnology & Biotechnological Equipment, 2019
This study presents an automated, image-based cytometry method for determination of total counts and viability of yeast cells by using a newly synthesized DNA fluorescent dye PO-TEDM-1 and a new Easycounter YC instrument.
Milka Atanasova   +5 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

open access: yesFEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey   +4 more
wiley   +1 more source

Cell permeable, fluorescent dye [PDF]

open access: yes
The invention pertains to a near-infrared fluorescent dye that is cell permeable and can be attached to selected proteins in living cells. The dye has the general formula (I) or its or its corresponding spirolactone (II) wherein Y is chosen from the ...
Johnsson, Kai   +2 more
core  

Microwave-assisted synthesis of polymer nanoparticles with physically entrapped fluorophores

open access: yesNano Research
Microwave irradiation has emerged as a highly advantageous alternative to conventional heating methods, with well-documented merits in the synthesis of diverse nanomaterials, including fluorescent nanomaterials.
Dan Li   +8 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Non-porous fluorescent dye stains: a comparative analysis [PDF]

open access: yes, 2010
A comparative study with the objective of identifying if Ardrox, MBD, and RAM fluorescent dye stains are equal to or better than the current fluorescent dye stains commonly used on fingerprint evidence: MRM-10, Rhodamine 6G, and Basic Yellow.
Waffle, Debra A.
core  

Preparation modified resins for solid-phase synthesis of RTPCR fluorescent probes

open access: yesТонкие химические технологии, 2009
Synthesis of library functional anchor groups with xanthene fluorescent dye on solid-phase support.
V. P. Goudov, V. G. Lunin, V. I. Shvets
doaj  

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