Results 91 to 100 of about 218,447 (350)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Towards rare-earth-free white light-emitting diode devices based on the combination of dicyanomethylene and pyranine as organic dyes supported on zinc single-layered hydroxide

Beilstein Journal of Nanotechnology, 2019
A new luminescent composite film resulting from the dispersion of luminescent organic dyes in a single-layered hydroxide (SLH)-type inorganic matrix has been developed.
Jeff L. Nyalosaso, Rachod Boonsin, Pierre Vialat, Damien Boyer, Geneviève Chadeyron, Rachid Mahiou, Fabrice Leroux   +6 more
doaj   +1 more source

Fluorescent AM1-43 and FM1-43 probes for dental sensory nerves and cells: Their labeling mechanisms and applications

Japanese Dental Science Review, 2011
This mini-review first introduces the fluorescent styryl dyes, AM1-43 and FM1-43, which stain a variety of sensory cells and tissues including sensory nerve fibers.
Sumio Nishikawa
doaj   +1 more source

Targeting the insulin growth factor-1 receptor with fluorescent antibodies enables high resolution imaging of human pancreatic cancer in orthotopic mouse models. [PDF]

, 2016
The goal of the present study was to determine whether insulin-like growth factor-1 receptor (IGF-1R) antibodies, conjugated with bright fluorophores, could enable visualization of pancreatic cancer in orthotopic nude mouse models. IGF-1R antibody (clone
Bouvet, Michael, Hoffman, Robert M, Lee, Jin Young, Park, Jeong Youp, Zhang, Yong   +4 more
core   +2 more sources

DiOlistics: Delivery of Fluorescent Dyes into Cells [PDF]

, 2012
DiOlistic labeling utilizes a particle-mediated delivery system to incorporate dye into cells. Because of its random nature, this technique generates sparse fluorescent labeling which is well suited for the study of neuronal dendritic branching and dendritic spine morphology.
Veronica A. Alvarez, Nyssa Sherazee
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

ASYMMETRIC, WATER-SOLUBLE CYANINE DYES: SYNTHESIS AND FLUORESCENT PROBE FOR THE Fe3+ ION

Studia Universitatis Babes-Bolyai Chemia
Two known symmetric and four novel asymmetric water-soluble pentamethyl cyanine dyes were synthesized and fully characterized by IR, MS and NMR. These dyes exhibited good water solubility and possessed good stability at different pH environment.
Xinyu DUAN, Weijian LI , Yanan NIU, Aihong HAN   +3 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Visible diode lasers can be used for flow cytometric immunofluorescence and DNA analysis [PDF]

, 1994
This report describes a feasibility study concerning the use of a visible diode laser for two important fluorescence applications in a flow cytometer. With a 3 mW 635 nm.
de Grooth, B.G., Doornbos, R.M.P., Doornbos, Richard M.P., Greve, Jan, Kraan, Yvonne M., van der Poel, Carel J.   +5 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source